ArticleVirchows Archiv : an international journal of pathology2003
Chymase-positive mast cells in small sized adenocarcinoma of the lung.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Targeting innate and adaptive immunity to suppress lung cancer metastasis.Frontiers in immunology · 2025Review
- Characteristics of mast cell infiltration in lung adenocarcinoma and its impact on prognosis.Discover oncology · 2024Article
- Levels of circulating mast cell progenitors and tumour‑infiltrating mast cells in patients with colorectal cancer.Oncology reports · 2022Article
- Mast cell-based molecular subtypes and signature associated with clinical outcome in early-stage lung adenocarcinoma.Molecular oncology · 2020Article
- Mast cell chymase: morphofunctional characteristics.Histochemistry and cell biology · 2019Review
- Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis.Oncotarget · 2018Article
- Mast cell chymase affects the proliferation and metastasis of lung carcinoma cellsOncology letters · 2017Article
- Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer.Scientific reports · 2016Article
- The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.BioMed research international · 2015Review
- Possible prognostic and therapeutic significance of c-Kit expression, mast cell count and microvessel density in renal cell carcinoma.International journal of molecular sciences · 2014Review
- Possible biological and translational significance of mast cells density in colorectal cancer.World journal of gastroenterology · 2014Review
- Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis.Journal of molecular histology · 2010Article
- Significance of neo-angiogenesis and immuno-surveillance cells in squamous cell carcinoma of the tongue.The Libyan journal of medicine · 2007Article
- Immunosurveillance function of human mast cell?World journal of gastroenterology · 2005Article
- Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer.World journal of gastroenterology · 2005Article
- Key role of mast cells and their major secretory products in inflammatory bowel disease.World journal of gastroenterology · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells accumulate in angiogenesis-dependent situations of lung adenocarcinoma. Human mast cells are divided into two major subsets: MCT (mast cells with immunoreactivity for tryptase but not chymase) and MCTC (reactive for tryptase and chymase). Chymase is an important mediator of tissue remodeling, but research into chymase-containing mast cell subpopulations has been hampered by the lack of reagents suitable for use with formalin-fixed tissue. We stained chymase using CC1 antibody in 66 cases of small sized lung adenocarcinoma as well as CD34 and tryptase. There were significant positive correlations of microvessel counts with MCT-type and MCTC-type mast cell counts in lung adenocarcinomas. When analyzed according to Noguchi's classification, MCT-type and MCTC-type mast cells were significantly increased in Noguchi type-C tumors [localized bronchioloalveolar carcinoma (LBAC) with active fibroblastic proliferation] compared with in Noguchi type-A (LBAC) plus type-B tumors (LBAC with alveolar collapse). Members in the high-count group of MCTC-type but not MCT-type mast cells showed a significantly worse outcome than those in the low-count group in LBACs. Counting chymase-positive (MCTC-type) mast cells in tumor stroma may be a good prognosis predictor for LBACs, especially Noguchi type-C tumors.
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