ArticleChromosoma2003
FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements.
Article in Chromosoma, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- The Green Valley ofCells · 2022Review
- Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes.Epigenetics & chromatin · 2020Article
- The True Story ofFrontiers in physiology · 2019Review
- Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila.PLoS genetics · 2016Article
- The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function.Chromosoma · 2015Review
- The Release 6 reference sequence of the Drosophila melanogaster genome.Genome research · 2015Article
- An integrated linkage, chromosome, and genome map for the yellow fever mosquito Aedes aegypti.PLoS neglected tropical diseases · 2013Article
- Imaginal discs--a new source of chromosomes for genome mapping of the yellow fever mosquito Aedes aegypti.PLoS neglected tropical diseases · 2011Article
- Functional antagonism between histone H3K4 demethylases in vivo.Genes & development · 2011Article
- Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2.Genetics · 2010Article
- Review
- High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster.Genetics · 2007Article
- Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster.Genetics · 2005Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster contains about 30 essential genes defined by genetic analysis. In the last decade only a few of these genes have been molecularly characterized and found to correspond to protein-coding genes involved in important cellular functions. Moreover, several predicted genes have been identified by annotation of genomic sequence that are associated with polytene chromosome divisions 40, 41 and 80 but their locations on the cytogenetic map of the heterochromatin are still uncertain. To expand our current knowledge of the genetic functions located in heterochromatin, we have performed fluorescence in situ hybridization (FISH) mapping to mitotic chromosomes of nine bacterial artificial chromosomes (BACs) carrying several predicted genes and of 13 P element insertions assigned to the proximal regions of 2R and 3L. We found that 22 predicted genes map to the h46 region of 2R and eight map to the h47 regions of 3L. This amounts to at least 30 predicted genes located in these heterochromatic regions, whereas previous studies detected only seven vital genes. Finally, another 58 genes localize either in the euchromatin-heterochromatin transition regions or in the proximal euchromatin of 2R and 3L.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.