ArticlePflugers Archiv : European journal of physiology2003
NH(4)(+) conductance in Xenopus laevis oocytes. III. Effect of NH(3).
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations.Bioscience reports · 2024Review
- Aquaporin 4 as a NH3 Channel.The Journal of biological chemistry · 2016Article
- PvAMT1;1, a highly selective ammonium transporter that functions as H+/NH4(+) symporter.The Journal of biological chemistry · 2011Article
- Sodium-bicarbonate cotransporter NBCn1/Slc4a7 inhibits NH4Cl-mediated inward current in Xenopus oocytes.Experimental physiology · 2011Article
- Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.Experimental physiology · 2010Article
- Substrate specificity of Rhbg: ammonium and methyl ammonium transport.American journal of physiology. Cell physiology · 2010Article
- Calcium dynamics during physiological acidification in Xenopus oocyte.The Journal of membrane biology · 2010Article
- Establishing a definitive stoichiometry for the Na+/monocarboxylate cotransporter SMCT1.Biophysical journal · 2007Article
- Ammonium ion transport by the AMT/Rh homologue LeAMT1;1.The Biochemical journal · 2006Article
- Amt/MEP/Rh proteins conduct ammonia.Pflugers Archiv : European journal of physiology · 2006Review
- Different transport mechanisms in plant and human AMT/Rh-type ammonium transporters.The Journal of general physiology · 2006Article
- Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG.American journal of physiology. Renal physiology · 2006Article
- Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.The Journal of general physiology · 2005Article
- NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes.Pflugers Archiv : European journal of physiology · 2005Article
- Electroneutral ammonium transport by basolateral rhesus B glycoprotein.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of Xenopus laevis oocytes to NH(4)Cl caused intracellular acidification, cell membrane depolarization and the generation of an inward current. To determine the contribution of uncharged NH(3) and positively charged NH(4)(+), the NH(4)Cl-induced inward current was measured in the presence of increasing [NH(3)] at constant [NH(4)Cl] (10 mM) or increasing [NH(4)Cl] at constant [NH(3)] (0.045 mM) with pH varying in both cases. At -70 mV, the NH(4)Cl-induced current was barely detectable at pH 6.5, 0.01 mM NH(3), but increased successively at pH 7.5, 0.1 mM NH(3) and pH 8.5, 1 mM NH(3). In contrast, NH(4)Cl-associated currents were independent of changes of the [NH(4)Cl] at constant [NH(3)] and variable pH. Similar results with respect to acidification, depolarization and inward current in response to concentration and pH changes were obtained with trimethylamine HCl. Increasing concentrations of the weak acid propionate led to a reduction of the NH(4)Cl-induced current. These data suggest that NH(3) entry may induce local alkalinization that, in turn, may trigger the opening of a conductance for NH(4)(+) or trimethylamine-H(+) entry.
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