ReviewEnvironmental health perspectives2003
The role of genetic polymorphisms in environmental health.
Review in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Pooled it
- Investigating the Urinary Metabolome in the First Year of Life and Its Association with Later Diagnosis of Autism Spectrum Disorder or Non-Typical Neurodevelopment in the MARBLES Study.International journal of molecular sciences · 2023Article
- A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico.Toxics · 2021Review
- Gene-environment interactions between air pollution and biotransformation enzymes and risk of birth defects.Birth defects research · 2021Article
- Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.Translational psychiatry · 2019Article
- Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study.International journal of environmental research and public health · 2019Article
- A Predictive Model Assessing Genetic Susceptibility Risk at Workplace.International journal of environmental research and public health · 2019Article
- Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.American journal of medical genetics. Part A · 2018Article
- C3435T polymorphism in theInternational journal of clinical and experimental pathology · 2018Article
- Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration.Oncotarget · 2016Article
- Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science.Journal of toxicology and environmental health. Part B, Critical reviews · 2016Review
- Congenital heart disease: the crossroads of genetics, epigenetics and environment.Current genomics · 2014Article
- Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.Environmental health : a global access science source · 2011Article
- GSTT1 and GSTM1 gene polymorphisms in European and African populations.Molecular biology reports · 2011Article
- Genetic variability in susceptibility to occupational respiratory sensitization.Journal of allergy · 2011Article
- Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.Nucleic acids research · 2011Article
- Article
- Gene-environment interaction and male reproductive function.Asian journal of andrology · 2010Review
- Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?Human genetics · 2008Review
- Consanguinity and birth defects in the jerusalem perinatal study cohort.Human heredity · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Interest is increasing in the role of variations in the human genome (polymorphisms) in modifying the effect of exposures to environmental health hazards (often referred to as gene-environment interaction), which render some individuals or groups in the population more or less likely to develop disease after exposure. This review is intended for an audience of environmental health practitioners and students and is designed to raise awareness about this rapidly growing field of research by presenting established and novel examples of gene-environment interaction that illustrate the major theme of effect modification. Current data gaps are identified and discussed to illustrate limitations of past research and the need for the application of more robust methods in future research projects. Two primary benefits of incorporating genetics into the existing environmental health research framework are illustrated: a) the ability to detect different levels of risk within the population, and b) greater understanding of etiologic mechanisms. Both offer opportunities for developing new methods of disease prevention. Finally, we describe a basic framework for researchers interested in pursuing health effects research that incorporates genetic polymorphisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.