ArticleThe Journal of physiology2003
Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 105 citations in OpenAlex.
- Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans.The Journal of physiology · 2012Trial
- Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans.The Journal of physiology · 2007Trial
- Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men.The Journal of physiology · 2005Trial
- Ageing exacerbates the adverse effects of respiratory muscle fatigue on vascular function, locomotor muscle fatigue and exercise performance in males.Experimental physiology · 2026Article
- Endogenous muscarinic acetylcholine receptor signaling blunts αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The blood flow and vascular responses in dynamically exercising skeletal muscles evoked by combination of cold stimulation and voluntary apnea in humans.European journal of applied physiology · 2025Article
- Vascular limitations in blood pressure regulation with age in women: Insights from exercise and acute cardioselective β-blockade.Experimental physiology · 2025Article
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex.Frontiers in physiology · 2023Review
- Matching of OFrontiers in physiology · 2022Review
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Nitric Oxide and Decreases in Resistance Exercise Blood Pressure With Aerobic Exercise Training in Older Individuals.Frontiers in physiology · 2019Article
- Microvascular mechanisms limiting skeletal muscle blood flow with advancing age.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise.Respiratory physiology & neurobiology · 2017Article
- Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, NaThe Journal of physiology · 2017Article
- Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Endothelium-dependent vasodilatory signalling modulates αThe Journal of physiology · 2016Article
- Article
- Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Regulation of skeletal muscle blood flow during exercise in ageing humans.The Journal of physiology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vasoconstrictor responsiveness to acute sympathetic stimulation declines with advancing age in resting skeletal muscle. The purpose of the present study was to determine if age-related reductions in sympathetic vasoconstrictor responsiveness also occur in exercising skeletal muscle. Thirteen younger (20-30 years) and seven older (62-74 years) healthy non-endurance-trained men performed cycle ergometer exercise at ~60 % of peak oxygen uptake while leg blood flow (femoral vein thermodilution), mean arterial blood pressure (radial artery catheter), and plasma adrenaline and noradrenaline concentrations were measured. After steady state was reached (i.e. ~4 min), acute sympathetic stimulation was achieved by immersing a hand in ice water for 2-4 min (cold pressor test, CPT). CPT tended to cause a larger increase in mean arterial blood pressure in older men (older (O): 16 +/- 3 mmHg; younger (Y): 10 +/- 2 mmHg) during exercise, but increases in arterial noradrenaline were similar (O: 2.56 +/- 0.96 nM; Y: 1.98 +/- 0.40 nM). However, the older men demonstrated a larger percentage reduction in exercising leg vascular conductance (leg blood flow/mean arterial pressure) during CPT compared to younger men (O: -13.6 +/- 3.1 %; Y: -1.5 +/- 4.3 %; P = 0.04). Leg blood flow tended to increase in the younger men, but not in the older men (P = 0.10). These results suggest, in contrast to what has been observed in resting skeletal muscle, that vasoconstrictor responsiveness to sympathetic stimulation is not reduced, but may be augmented in exercising muscle of healthy older humans. This could reflect a reduced ability of local substances (e.g. nitric oxide) to impair vasoconstriction in response to sympathetic stimulation during exercise in older humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.