ArticleThe Journal of physiology2003
cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Distinct interhemispheric connectivity at the level of the olfactory bulb emerges during Xenopus laevis metamorphosis.Cell and tissue research · 2021Article
- Olfaction across the water-air interface in anuran amphibians.Cell and tissue research · 2021Review
- Interhemispheric asymmetry of c-Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation.FEBS open bio · 2020Article
- Conservation of Glomerular Organization in the Main Olfactory Bulb of Anuran Larvae.Frontiers in neuroanatomy · 2020Article
- One Special Glomerulus in the Olfactory Bulb of Xenopus laevis Tadpoles Integrates a Broad Range of Amino Acids and Mechanical Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Olfactory experiences dynamically regulate plasticity of dendritic spines in granule cells of Xenopus tadpoles in vivo.Scientific reports · 2016Article
- Integrating temperature with odor processing in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- In Vivo Study of Dynamics and Stability of Dendritic Spines on Olfactory Bulb Interneurons in Xenopus laevis Tadpoles.PloS one · 2015Article
- Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.PloS one · 2014Article
- Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.Cellular and molecular life sciences : CMLS · 2013Article
- The styryl dye FM1-43 suppresses odorant responses in a subset of olfactory neurons by blocking cyclic nucleotide-gated (CNG) channels.The Journal of biological chemistry · 2011Article
- Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles.Purinergic signalling · 2010Article
- The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A new challenge-development of test systems for the infochemical effect.Environmental science and pollution research international · 2009Review
- Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis.The Journal of physiology · 2007Article
- Cannabinoid action in the olfactory epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Classes and narrowing selectivity of olfactory receptor neurons of Xenopus laevis tadpoles.The Journal of general physiology · 2004Article
- Identification of second messenger mediating signal transduction in the olfactory receptor cell.The Journal of general physiology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether odorants are transduced by only one or more than one second messenger has been a long-standing question in olfactory research. In a previous study we started to address this question mainly by using calcium imaging in the olfactory bulb. Here, we present direct evidence for our earlier conclusions using the calcium imaging technique in the mucosa slice. The above question can now unambiguously be answered. We show that some olfactory receptor neurons (ORNs) respond to stimulation with amino acids with an increase of the intracellular calcium concentration [Ca2+]i. In order to see whether or not these responses were mediated by the cAMP transduction pathway we applied forskolin or the membrane-permeant cAMP analogue pCPT-cAMP to the olfactory epithelium. The ensemble of ORNs that was activated by amino acids markedly differed from the ensemble of neurons activated by forskolin or pCPT-cAMP. Less than 6 % of the responding ORNs showed a response to both amino acids and the pharmacological agents activating the cAMP transduction pathway. We conclude that ORNs of Xenopus laevis tadpoles have both cAMP-dependent and cAMP-independent olfactory transduction pathways and that most amino acids are transduced in a cAMP-independent way.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.