ArticleThe Journal of physiology2003
Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Maternal taurine as a modulator of ClFrontiers in cellular neuroscience · 2023Review
- Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development.Metabolites · 2022Article
- Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons.Frontiers in molecular neuroscience · 2022Article
- Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases.Biomolecules · 2020Review
- Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency.Scientific reports · 2017Article
- Taurine as an Essential Neuromodulator during Perinatal Cortical Development.Frontiers in cellular neuroscience · 2017Review
- Ammonia-induced miRNA expression changes in cultured rat astrocytes.Scientific reports · 2016Article
- Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats.Frontiers in cellular neuroscience · 2014Article
- Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2.The European journal of neuroscience · 2013Article
- Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors.PloS one · 2013Article
- Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.The Journal of biological chemistry · 2012Article
- Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice.Cellular and molecular neurobiology · 2012Article
- Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- L-Dopa activates histaminergic neurons.The Journal of physiology · 2011Article
- Modulation of calcium channels by taurine acting via a metabotropic-like glycine receptor.Cellular and molecular neurobiology · 2010Article
- Intermittent high-dose ethanol exposures increase motivation for operant ethanol self-administration: possible neurochemical mechanism.Brain research · 2010Article
- Developmental alterations of DHPG-induced long-term depression of corticostriatal synaptic transmission: switch from NMDA receptor-dependent towards CB1 receptor-dependent plasticity.Pflugers Archiv : European journal of physiology · 2009Article
- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.The Journal of physiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taurine, a major osmolyte in the brain evokes a long-lasting enhancement (LLETAU) of synaptic transmission in hippocampal and cortico-striatal slices. Hippocampal LLETAU was abolished by the GABA uptake blocker nipecotic acid (NPA) but not by the taurine-uptake inhibitor guanidinoethyl sulphonate (GES). Striatal LLETAU was sensitive to GES but not to NPA. Semiquantitative PCR analysis and immunohistochemistry revealed that taurine transporter expression is significantly higher in the striatum than in the hippocampus. Taurine transporter-deficient mice displayed very low taurine levels in both structures and a low ability to develop LLETAU in the striatum, but not in the hippocampus. The different mechanisms of taurine-induced synaptic plasticity may reflect the different vulnerabilities of these brain regions under pathological conditions that are accompanied by osmotic changes such as hepatic encephalopathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.