Evidence map›Paper›PMID 12824331›Full record

ArticleNucleic acids research2003

Tools for comparative protein structure modeling and analysis.

Narayanan Eswar, Bino John, Nebojsa Mirkovic, Andras Fiser, Valentin A Ilyin, Ursula Pieper, Ashley C Stuart, Marc A Marti-Renom, M S Madhusudhan, Bozidar Yerkovich and 1 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed.

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  12. Activation dynamics of ubiquitin-specific protease 7.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  15. Article
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  17. MuToN Quantifies Binding Affinity Changes upon Protein Mutations by Geometric Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  18. Review
  19. Article
  20. Article

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Narayanan EswarDepartment of Biopharmaceutical Sciences and California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94143-2240, USA.
Bino John
Nebojsa Mirkovic
Andras Fiser
Valentin A Ilyin
Ursula Pieper
Ashley C Stuart
Marc A Marti-Renom
M S Madhusudhan
Bozidar Yerkovich
Andrej Sali

Funding

CENTER FOR STRUCTURAL GENOMICSP50GM062529 · NIGMS · SGX PHARMACEUTICALS, INC. · PI BURLEY, STEPHEN KEVIN · 2000 to 2004
$33.8M
Protein Modeling by Satisfaction of Spatial RestraintsR01GM054762 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2001 to 2008
$2.1M
TARGET SELECTION FOR THE STRUCTURAL GENOMICS OF CANCERR33CA084699 · NCI · ROCKEFELLER UNIVERSITY · PI GAASTERLAND, THERESA · 2000 to 2002
$1.1M
NCI NIH HHS R33 CA84699NIGMS NIH HHS P50 GM062529NIGMS NIH HHS P50 GM62529NIGMS NIH HHS R01 GM054762NIGMS NIH HHS R01 GM 54762
6 · The paper itself

Abstract

The following resources for comparative protein structure modeling and analysis are described (http://salilab.org): MODELLER, a program for comparative modeling by satisfaction of spatial restraints; MODWEB, a web server for automated comparative modeling that relies on PSI-BLAST, IMPALA and MODELLER; MODLOOP, a web server for automated loop modeling that relies on MODELLER; MOULDER, a CPU intensive protocol of MODWEB for building comparative models based on distant known structures; MODBASE, a comprehensive database of annotated comparative models for all sequences detectably related to a known structure; MODVIEW, a Netscape plugin for Linux that integrates viewing of multiple sequences and structures; and SNPWEB, a web server for structure-based prediction of the functional impact of a single amino acid substitution.

Indexed as

SoftwareStructural Homology, ProteinInternetModels, MolecularProtein FoldingProteinsReproducibility of ResultsSequence AlignmentSequence Homology, Amino AcidSystems IntegrationProteins

Identifiers

PMID12824331
PMCPMC168950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.