ArticleClinical and experimental immunology2003
Age-related accumulation of Ig V(H) gene somatic mutations in peripheral B cells from aged humans.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults: analysis of the variable heavy chain repertoire.Infection and immunity · 2005Trial
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- Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway.Biomedicines · 2023Review
- T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.Scientific reports · 2023Article
- mTOR and Aging: An Old Fashioned Dress.International journal of molecular sciences · 2019Review
- De novo gene mutations in normal human memory B cells.Leukemia · 2019Article
- Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.Cell host & microbe · 2019Article
- The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age.Immunity & ageing : I & A · 2019Article
- Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.The Journal of allergy and clinical immunology · 2016Article
- Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.PloS one · 2014Article
- Kidney transplantation and the ageing immune system.Nature reviews. Nephrology · 2012Review
- AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans.PLoS pathogens · 2012Article
- Aging affects human B cell responses.Journal of clinical immunology · 2011Review
- CD20 deficiency in humans results in impaired T cell-independent antibody responses.The Journal of clinical investigation · 2010Article
- Article
- Germinal centers in human lymph nodes contain reactivated memory B cells.The Journal of experimental medicine · 2007Article
- Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate age-related alterations in human humoral immunity, we analysed Ig heavy chain variable region genes expressed by peripheral B cells from young and aged individuals. Three hundred and twenty-seven cDNA sequences, 163 micro and 164 gamma transcripts with VH5 family genes, were analysed for somatic hypermutation and VHDJH recombinational features. Unmutated and mutated micro transcripts were interpreted as being from naive and memory IgM B cells, respectively. In young and aged individuals, the percentages of naive IgM among total micro transcripts were 39% and 42%, respectively. D and JH segment usage in naive IgM from aged individuals was similar to that from young individuals. The mutational frequencies of memory IgM were similar in young and aged individuals. gamma transcripts, which are regarded as being from memory IgG B cells, showed a significantly higher mutational frequency (7.6%) in aged than in young individuals (5.8%) (P < 0.01). These findings suggest that VHDJH recombinational diversity was preserved, but that the accumulation of somatic mutations in the IgG VH region was increased in aged humans. The accumulation of somatic mutations in IgG B cells during ageing may imply that an age-related alteration exists in the selection and/or maintenance of peripheral memory B cells.
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