ArticleDigestive diseases and sciences2003
Absence of luminal riboflavin disturbs early postnatal development of the gastrointestinal tract.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Dietary Riboflavin Requirement of Pacific White Shrimp (Aquaculture nutrition · 2023Article
- Effects of nano-selenium on cecum microbial community and metabolomics in chickens challenged with Ochratoxin A.Frontiers in veterinary science · 2023Article
- Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota.Frontiers in microbiology · 2023Article
- B Vitamins and Their Roles in Gut Health.Microorganisms · 2022Review
- Riboflavin depletion of intestinal cells in vitro leads to impaired energy generation and enhanced oxidative stress.European journal of nutrition · 2013Article
- Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors.Digestive diseases and sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in the size and cellularity of duodenal crypts and a decreased incidence of bifurcating crypts is observed in response to very short-term feeding of a riboflavin-deficient diet to weanling rats. A study was conducted to determine whether the absence of riboflavin in the lumen of the small intestine impairs gastrointestinal development. Forty-eight female weanling Wistar rats were allocated to one of two treatment regimens, to receive either a riboflavin-deficient diet and a daily intraperitoneal injection of flavin mononucleotide (luminally deficient group) or a complete diet and a daily intraperitoneal injection of saline (control group). Animals were killed at 93, 141, or 165 hr from feeding. The flavin injection regimen maintained normal systemic riboflavin status in the luminally deficient group. In this group, however, crypt hypertrophy and reduced crypt bifurcation were evident by 141 hr of luminal riboflavin deprivation. The absence of riboflavin in the duodenal lumen impairs normal development, suggesting that a crypt sensing mechanism may be involved in the response to riboflavin deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.