Trial reportMetabolic brain disease2003
Reproducibility of the lactate stress test.
Trial report in Metabolic brain disease, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Diagnostic accuracy of the lactate stress test for detecting mitochondrial disorders: Systematic review and meta-analysis.Heliyon · 2024Article
- Exercise Testing, Physical Training and Fatigue in Patients with Mitochondrial Myopathy Related to mtDNA Mutations.Journal of clinical medicine · 2021Review
- Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression.Chinese medical journal · 2016Article
- Phenotypic Heterogeneity of the m.14459G>A Mutation.Child neurology openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the lactate stress test has been shown to be a powerful tool to screen for respiratory chain disorders, little is known about the reproducibility of this test. The aim of the present study was thus to look for the reliability of the lactate stress test in disease controls and patients with primary respiratory chain disorders. In 23 patients with respiratory chain disorder, 16 women and 7 men, aged 36-81 years, and 18 disease controls, 5 women and 18 men, aged 37-70 years, the lactate stress test was carried out when respiratory chain disorder was suspected for the first time and at the first follow-up. The sensitivity of the first lactate stress test was 81% and the specificity 72%. The sensitivity of the second lactate stress test was 74% and the specificity 61%. The reproducibility of the lactate stress test was 65% in patients with respiratory chain disorders and 78% in disease controls. In conclusion, this study shows that the sensitivity, specificity, and reproducibility of the lactate stress test is high enough to warrant its application as a reliable, supplementary method to search for respiratory chain disorders.
Indexed as
Identifiers
12822834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.