ArticleThe Journal of physiology1992
Stretch-activated non-selective cation channels in the antiluminal membrane of porcine cerebral capillaries.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 81 citations in OpenAlex.
- Alterations in brain fluid physiology during the early stages of development of ischaemic oedema.Fluids and barriers of the CNS · 2024Review
- Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a comparative account of mechanisms and roles.Fluids and barriers of the CNS · 2016Review
- Swelling-activated and arachidonic acid-induced currents are TREK-1 in rat bladder smooth muscle cells.Fukushima journal of medical science · 2016Article
- Cardiac Mechano-Gated Ion Channels and Arrhythmias.Circulation research · 2016Review
- Non-channel mechanosensors working at focal adhesion-stress fiber complex.Pflugers Archiv : European journal of physiology · 2015Review
- Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation.Ultrasound in medicine & biology · 2010Article
- Membrane stretching triggers mechanosensitive Ca2+ channel activation in Chara.The Journal of membrane biology · 2009Article
- Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells.Pflugers Archiv : European journal of physiology · 2008Article
- Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium.The Journal of physiology · 2004Article
- Ca(2+)- and voltage-dependent gating of Ca(2+)- and ATP-sensitive cationic channels in brain capillary endothelium.Biophysical journal · 2003Article
- Na+-Ca2+ exchange and its implications for calcium homeostasis in primary cultured rat brain microvascular endothelial cells.The Journal of physiology · 1999Article
- A transferable, beta-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells.The Journal of physiology · 1996Article
- Up-regulation of pressure-activated Ca(2+)-permeable cation channel in intact vascular endothelium of hypertensive rats.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Classification of ion channels in the luminal and abluminal membranes of guinea-pig endocardial endothelial cells.The Journal of physiology · 1995Article
- Ca2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Single stretch-activated (SA) channels have been studied in isolated brain capillary endothelial cells as well as in the antiluminal membrane of intact porcine cerebral capillaries using the patch-clamp recording technique. 2. The SA channels were found to be cation selective and permeable to Na+, K+, Ba2+ and Ca2+. 3. With monovalent cations in the patch pipette, the channels showed inward rectification in cell-attached patches with a single-channel conductance of 37 pS at negative and 24 pS at positive clamp potentials. 4. With either 70 mM-Ca2+ or Ba2+ in the patch pipette, the current-voltage relation was linear with slope conductances of 16 and 19 pS, respectively. 5. Mean channel open probability increased with increasing pressure and with depolarizing clamp potentials. 6. Cell swelling induced by hypotonic shock activated the SA channels in cell-attached experiments. 7. The SA channel may be involved in cell volume or blood flow regulation. The contribution of these channels to the regulation of cerebrospinal salt and water content, especially in brain oedema, is discussed.
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