Evidence map›Paper›PMID 12821488›Full record

ArticleAntimicrobial agents and chemotherapy2003

Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.

Ralf René Reinert, Angela Wild, Peter Appelbaum, Rudolf Lütticken, Murat Yücel Cil, Adnan Al-Lahham

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2004
    Guideline
  2. Review
  3. Bacterial Resistance to Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ralf René ReinertInstitute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany. reinert@rwth-aachen.de
Angela Wild
Peter Appelbaum
Rudolf Lütticken
Murat Yücel Cil
Adnan Al-Lahham
Institute of Medical Microbiology and Hygiene · DEHershey (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialGenotypeGermanyMacrolidesMolecular Sequence DataPoint MutationRibosomal ProteinsRNA, Ribosomal, 23SStreptococcus pneumoniaeAnti-Bacterial AgentsMacrolidesribosomal protein L4Ribosomal ProteinsRNA, Ribosomal, 23S

Identifiers

PMID12821488
PMCPMC161879
OpenAlexW2165940136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.