ArticleAntimicrobial agents and chemotherapy2003
Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Elimination of Non-cytopathic Bovine Viral Diarrhea Virus From the LFBK-αFrontiers in veterinary science · 2021Article
- Cycluridine: A novel antiviral effective against flaviviruses.Antiviral chemistry & chemotherapy · 2017Review
- Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System.Antimicrobial agents and chemotherapy · 2016Article
- Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Article
- Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells.PloS one · 2012Article
- A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.Journal of virology · 2006Article
- The synthesis of dicationic extended bis-benzimidazoles.Molecules (Basel, Switzerland) · 2004Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Bovine viral diarrhea virus (BVDV) is an economically significant pathogen of cattle and a problematic contaminant in the laboratory. BVDV is often used as an in vitro model for hepatitis C virus during drug discovery efforts. Aromatic dicationic molecules have exhibited inhibitory activity against several RNA viruses. Thus, the purpose of this research was to develop and apply a method for screening the aromatic cationic compounds for in vitro cytotoxicity and activity against a noncytopathic strain of BVDV. The screening method evaluated the concentration of BVDV in medium and cell lysates after 72 h of cell culture in the presence of either a 25 or 5 microM concentration of the test compound. Five of 93 screened compounds were selected for further determination of inhibitory (90 and 50%) and cytotoxic (50 and 10%) concentration endpoints. The screening method identified compounds that exhibited inhibition of BVDV at nanomolar concentrations while exhibiting no cytotoxicity at 25 microM concentrations. The leading compounds require further investigation to determine their mechanism of action, in vivo activity, and specific activity against hepatitis C virus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.