ArticleCell stress & chaperones2003
Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training.
Article in Cell stress & chaperones, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Heat acclimation-induced intracellular HSP70 in humans: a meta-analysis.Cell stress & chaperones · 2020Pooled it
- Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.The journal of physiological sciences : JPS · 2023Article
- Former CSSI President Tangchun Wu elected to the Chinese Academy of Engineering.Cell stress & chaperones · 2022Article
- Impacts of previous heatstroke history on physiological parameters eHSP72 and biomarkers of oxidative stress in military working dogs.Cell stress & chaperones · 2019Article
- Hospitalized dogs recovery from naturally occurring heatstroke; does serum heat shock protein 72 can provide prognostic biomarker?Cell stress & chaperones · 2016Article
- Relationship Between Job Burnout and Neuroendocrine Indicators in Soldiers in the Xinjiang Arid Desert: A Cross-Sectional Study.International journal of environmental research and public health · 2015Article
- COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study.Cell stress & chaperones · 2015Article
- Basal and stress-induced Hsp70 are modulated by ataxin-3.Cell stress & chaperones · 2012Article
- The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma.Journal of experimental pharmacology · 2010Article
- The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.Cell stress & chaperones · 2009Article
- Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis.Digestive diseases and sciences · 2008Article
- Using lymphocyte and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers.Environmental health perspectives · 2007Article
- Association of increased heat shock protein 70 levels in the lymphocyte with high risk of adverse pregnancy outcomes in early pregnancy: a nested case-control study.Cell stress & chaperones · 2007Article
- Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?Cell stress & chaperones · 2006Review
- Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.Respiratory research · 2005Article
- Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population.Cell stress & chaperones · 2005Article
- Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population.Cell stress & chaperones · 2004Article
- Frequency-specific association of antibodies against heat shock proteins 60 and 70 with noise-induced hearing loss in Chinese workers.Cell stress & chaperones · 2004Article
- Introducing Professor Masataka Mori, Asia-Australian Regional Editor.Cell stress & chaperones · 2003Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (Hsps) or stress proteins, and, in particular, the inducible, cytosolic Hsp70, represent a highly conserved response to heat exposure and to a variety of noxious stimuli. Many investigations have shown correlations between the aberrant expression of Hsps and disease states. Whether the basal and inducible levels of Hsp70 are of any biological significance in patients with heat-induced diseases remains unknown. In the present study, we compared the basal and inducible levels of Hsp70 by flow cytometry in lymphocytes of patients with heat-induced diseases and after recovery from this disease, and in matched controls. Both groups comprised individuals who exercised by running in the same hot environment. The level of inducible Hsp70 was also measured after a heat treatment of lymphocytes in vitro. The results show that there is variation of basal and inducible Hsp70 levels among individuals. However, the group of patients suffering from heat-induced illnesses in May shows a significantly higher basal (P = 0.02) level of Hsp70 than does the control group. Individuals who have an increased level of Hsp70 may be more sensitive to heat or may respond differently. The level of Hsp70 may represent a biomarker to evaluate whether they are more susceptible to stresses than other individuals. Interestingly, the basal level of Hsp70 is higher in both the patient group and the control group in November than in May. In fact, the basal levels of Hsp70 in the patient and control groups are essentially the same in November, perhaps reflecting the successful stress conditioning of both groups.
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