ArticleCell stress & chaperones2003
Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans.
Article in Cell stress & chaperones, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 72 citations in OpenAlex.
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- Long-Term Culture of Individual Caenorhabditis elegans on Solid Media for Longitudinal Fluorescence Monitoring and Aversive Interventions.Journal of visualized experiments : JoVE · 2022Article
- Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations.Journal of visualized experiments : JoVE · 2021Article
- Host Immunity Alters Community Ecology and Stability of the Microbiome in a Caenorhabditis elegans Model.mSystems · 2021Article
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- Respiratory analysis as a tool to detect physiological changes in Anisakis larvae subjected to stress.Parasitology research · 2019Article
- Measurement of Oxygen Consumption Rates in Intact Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2019Article
- LED based real-time survival bioassays for nematode research.Scientific reports · 2018Article
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- Rapid and gentle hydrogel encapsulation of living organisms enables long-term microscopy over multiple hours.Communications biology · 2018Article
- C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles' uptake and toxicity assay.Scientific reports · 2017Article
- A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.Nature protocols · 2016Article
- Maintenance of Membrane Integrity and Permeability Depends on a Patched-Related Protein in Caenorhabditis elegans.Genetics · 2016Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, sodium azide has been used to anesthetize the nematode Caenorhabditis elegans; however, the mechanism by which it survives this exposure is not understood. In this study, we report that exposure of wild-type C elegans to 10 mM sodium azide for up to 90 minutes confers thermotolerance (defined as significantly increased survival probability [SP] at 37 degrees C) on the animal. In addition, sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed enhanced Hsp70 expression, whereas Western blot analysis revealed the induction of Hsp16. We also tested the only known C elegans Hsp mutant def-21 (codes for Hsp90), which constitutively enters the stress-resistant state known as the dauer larvae. Daf-21 mutants also acquire sodium azide-induced thermotolerance, whereas 3 non-Hsp, constitutive dauer-forming mutants exhibited a variable response to azide exposure. We conclude that the ability of C elegans to survive exposure to azide is associated with the induction of at least 2 stress proteins.
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