ReviewCurrent genetics2003
Adaptation to environmental pH in Candida albicans and its relation to pathogenesis.
Review in Current genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 95 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed.
- Probiotic and Postbiotic Interactions ofAntibiotics (Basel, Switzerland) · 2026Article
- Insights into the mechanisms of infection transmission via inanimate surfaces.Frontiers in microbiology · 2026Review
- The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026Review
- Transcriptional Responses to Alkaline pH Across Fungi: Common and Differential Features, and Biotechnological Applications.International journal of molecular sciences · 2025Review
- Pathogenic Fungal Sensing and Responses to Stressful Host Environments.Annual review of microbiology · 2025Review
- Coordinated regulation of pH alkalinization by two transcription factors promotes fungal commensalism and pathogenicity.Nature communications · 2025Article
- In Vitro Acid Resistance of PathogenicGastro hep advances · 2025Article
- An overview of the mechanistic approaches of antifungal nanomaterials.Frontiers in pharmacology · 2025Review
- Metabolite profiling and adaptation mechanisms ofFrontiers in microbiology · 2025Article
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- Malassezia responds to environmental pH signals through the conserved Rim/Pal pathway.bioRxiv : the preprint server for biology · 2024Article
- Fungal biofilm formation and its regulatory mechanism.Heliyon · 2024Review
- Article
- Morphology, Development, and Pigment Production of Talaromyces marneffei are Diversely Modulated Under Physiologically Relevant Growth Conditions.Current microbiology · 2024Article
- Transcriptional expression ofMicrobiology spectrum · 2024Article
- Investigating The Antifungal Activity of Atorvastatin Compared with Nystatin on Oral Candidiasis before and during Head and Neck Radiotherapy.Galen medical journal · 2024Review
- Antifungal effect of atorvastatin in comparison with fluconazole onDental research journal · 2024Article
- A glycosylated Phr1 protein is induced by calcium stress and its expression is positively controlled by the calcium/calcineurin signaling transcription factor Crz1 in Candida albicans.Cell communication and signaling : CCS · 2023Article
- Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development.International journal of oral science · 2023Article
- The Cdc25 and Ras1 Proteins ofJournal of fungi (Basel, Switzerland) · 2023Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For microorganisms that grow over a wide range of extracellular pH, systems must have evolved to sense and respond appropriately. The human opportunistic pathogen Candida albicans colonizes and infects anatomical sites of diverse pH, including the oral and gastro-intestinal tracts and the vaginal cavity. The ability to sense and respond to neutral-alkaline environments is governed by signal transduction pathways, one of which culminates in the activation of the transcription factor, Rim101p. The RIM101/pacC pathway, which governs pH responses and differentiation, has been the focus of study in both Saccharomyces cerevisiae and Aspergillus nidulans. This pathway has been identified in C. albicans and governs pH responses, dimorphism, and pathogenesis. Although C. albicans and S. cerevisiae are related fungi, it is becoming apparent that there are unique aspects of the pH response and the role the RIM101 pathway plays in this response in C. albicans.
Indexed as
Identifiers
12819929What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.