ArticlePlant cell reports2003
Rhizosecretion of recombinant proteins from plant hairy roots.
Article in Plant cell reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Nicotiana hairy roots for recombinant protein expression, where to start? A systematic review.Molecular biology reports · 2023Pooled it
- Optimized protocol for efficient generation, confirmation, transformation, and CRISPR editing of grapevine hairy roots.Journal of experimental botany · 2026Article
- NovelMicroorganisms · 2024Article
- Root Exudates: Mechanistic Insight of Plant Growth Promoting Rhizobacteria for Sustainable Crop Production.Frontiers in microbiology · 2022Review
- Hairy root culture technology: applications, constraints and prospect.Applied microbiology and biotechnology · 2021Review
- Optimised production of an anti-fungal antibody in Solanaceae hairy roots to develop new formulations against Candida albicans.BMC biotechnology · 2020Article
- Arabidopsis Hairy Roots Producing High Level of Active Human Gastric Lipase.Molecular biotechnology · 2020Article
- Production of a Recombinant Dermaseptin Peptide in Nicotiana tabacum Hairy Roots with Enhanced Antimicrobial Activity.Molecular biotechnology · 2019Article
- Production of Recombinant Anti-Cancer Vaccines in Plants.Biomolecules & therapeutics · 2017Review
- Article
- Hairy root biotechnology--indicative timeline to understand missing links and future outlook.Protoplasma · 2015Review
- Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2014Review
- Production of pharmaceutical proteins in solanaceae food crops.International journal of molecular sciences · 2013Article
- Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures.Plant cell reports · 2012Review
- Molecular Pharming: future targets and aspirations.Human vaccines · 2011Review
- Preventing unintended proteolysis in plant protein biofactories.Plant biotechnology journal · 2008Review
- Expression of recombinant Digitalis lanata EHRH. cardenolide 16'-O-glucohydrolase in Cucumis sativus L. hairy roots.Plant cell reports · 2006Article
- Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots.Plant physiology · 2006Article
- Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells.BMC biotechnology · 2005Article
- A quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots.Plant cell reports · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhizosecretion of a target protein in the hydroponic medium provides an alternative manufacturing platform that simplifies the downstream purification procedure and increases protein yield. In order to increase the production rates of rhizosecreted proteins, we have exploited the ability of Agrobacterium rhizogenes to induce the formation of large amounts of root tissue on transgenic tobacco plants engineered to secrete a model recombinant protein, human secreted alkaline phosphatase (SEAP). The secretion of SEAP from hairy roots induced on the stems of transgenic tobacco plants was 5-7 times higher than that from adventitious transgenic roots.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.