ArticleGenome research2003
The mammalian protein-protein interaction database and its viewing system that is linked to the main FANTOM2 viewer.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.The Journal of biological chemistry · 2010Article
- Linking the ovarian cancer transcriptome and immunome.BMC systems biology · 2008Article
- Ulysses - an application for the projection of molecular interactions across species.Genome biology · 2005Article
- Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.Genome research · 2003Article
- Inferring higher functional information for RIKEN mouse full-length cDNA clones with FACTS.Genome research · 2003Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we describe the development of a mammalian protein-protein interaction (PPI) database and of a PPI Viewer application to display protein interaction networks (http://fantom21.gsc.riken.go.jp/PPI/). In the database, we stored the mammalian PPIs identified through our PPI assays (internal PPIs), as well as those we extracted and processed (external PPIs) from publicly available data sources, the DIP and BIND databases and MEDLINE abstracts by using FACTS, a new functional inference and curation system. We integrated the internal and external PPIs into the PPI database, which is linked to the main FANTOM2 viewer. In addition, we incorporated into the PPI Viewer information regarding the luciferase reporter activity of internal PPIs and the data confidence of external PPIs; these data enable visualization and evaluation of the reliability of each interaction. Using the described system, we successfully identified several interactions of biological significance. Therefore, the PPI Viewer is a useful tool for exploring FANTOM2 clone-related protein interactions and their potential effects on signaling and cellular communication.
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