ArticleGenome research2003
The mouse secretome: functional classification of the proteins secreted into the extracellular environment.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Proteome-Wide Analysis and Surface Protein Isolation for Secretome Characterization Reveal Insights into the Biology of the Leaf-Cutter AntAnalytical chemistry · 2025Article
- Ovochymase 2 is a key regulatory factor modulating proteolytic pathways and sperm maturation in the mammalian epididymis†.Biology of reproduction · 2025Article
- CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.Andrology · 2024Article
- Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape.Frontiers in endocrinology · 2023Article
- Placental secretome characterization identifies candidates for pregnancy complications.Communications biology · 2021Article
- Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy.Cardiovascular research · 2020Article
- Secretome identification of immune cell factors mediating metastatic cell homing.Scientific reports · 2015Article
- In vivo selection of novel biotherapeutics.Oncotarget · 2015Article
- AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia.Nature communications · 2015Article
- Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.Nature medicine · 2015Article
- MetazSecKB: the human and animal secretome and subcellular proteome knowledgebase.Database : the journal of biological databases and curation · 2015Article
- Protein mobility within secretory granules.Biophysical journal · 2014Article
- Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy.Gastrointestinal cancer : targets and therapy · 2014Article
- Methodologies to decipher the cell secretome.Biochimica et biophysica acta · 2013Review
- Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.PloS one · 2013Article
- A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome.BMC genomics · 2012Article
- Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity.Journal of neuroinflammation · 2012Article
- Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations.Nature protocols · 2012Article
- Regulation of oocyte and cumulus cell interactions by intermedin/adrenomedullin 2.The Journal of biological chemistry · 2011Article
- Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion.Journal of proteome research · 2010Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
We have developed a computational strategy to identify the set of soluble proteins secreted into the extracellular environment of a cell. Within the protein sequences predominantly derived from the RIKEN representative transcript and protein set, we identified 2033 unique soluble proteins that are potentially secreted from the cell. These proteins contain a signal peptide required for entry into the secretory pathway and lack any transmembrane domains or intracellular localization signals. This class of proteins, which we have termed the mouse secretome, included >500 novel proteins and 92 proteins <100 amino acids in length. Functional analysis of the secretome included identification of human orthologs, functional units based on InterPro and SCOP Superfamily predictions, and expression of the proteins within the RIKEN READ microarray database. To highlight the utility of this information, we discuss the CUB domain-containing protein family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.