ArticleInfection and immunity2003
Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Key thermally dimorphic fungal pathogens: shaping host immunity.Open biology · 2022Review
- Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis.ImmunoHorizons · 2022Article
- Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi.Frontiers in cellular and infection microbiology · 2020Review
- Helper T-cell responses and pulmonary fungal infections.Immunology · 2018Review
- Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2Mucosal immunology · 2017Article
- Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.Cellular and molecular life sciences : CMLS · 2015Review
- Histoplasma capsulatum, lung infection and immunity.Future microbiology · 2015Review
- Review
- T-cell Subsets and Antifungal Host Defenses.Current fungal infection reports · 2010Article
- Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.The Journal of infectious diseases · 2010Article
- Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection.Infection and immunity · 2010Article
- The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Methamphetamine enhances histoplasmosis by immunosuppression of the host.The Journal of infectious diseases · 2009Article
- T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum.The Journal of infectious diseases · 2006Article
- Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.The Journal of clinical investigation · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines. Since interleukin-4 (IL-4) can inhibit both Th1 cytokine production and activity, we examined the effects of overproduction of IL-4 in the lung on the course of pulmonary histoplasmosis. IL-4 lung transgenic mice manifested a higher fungal burden in their lungs, but not spleens, compared to wild-type infected controls. Despite the higher burden, the transgenic animals were ultimately capable of controlling infection. The adverse effects of IL-4 on H. capsulatum elimination were not observed during the early phase of infection (days 1 to 3) but were maximal at day 7 postinfection, prior to the induction of cell-mediated immunity. Analysis of total body and lung cytokine levels revealed that gamma interferon and tumor necrosis factor alpha production were not inhibited in the presence of excess IL-4. Our results with transgenic mice were supported by additional in vivo studies in which allergen induction of pulmonary IL-4 was associated with delayed clearance of H. capsulatum yeast and increased fungal burden. These findings demonstrate that excess production of endogenous IL-4 modulates protective immunity to H. capsulatum by delaying clearance of the organism but does not prevent the generation of a Th1 response that ultimately controls infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.