ArticleThe Journal of membrane biology1992
Gating of retinal rod cation channel by different nucleotides: comparative study of unitary currents.
Article in The Journal of membrane biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Structural insights into the mechanisms of CNBD channel function.The Journal of general physiology · 2018Review
- The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.Current pharmaceutical design · 2006Review
- Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Efficient coupling of ligand binding to channel opening by the binding domain of a modulatory (beta) subunit of the olfactory cyclic nucleotide-gated channel.The Journal of general physiology · 2001Article
- Cyclic nucleotide-gated channels: shedding light on the opening of a channel pore.Nature reviews. Neuroscience · 2001Review
- Mechanism of inhibition of cyclic nucleotide-gated ion channels by diacylglycerol.The Journal of general physiology · 2000Article
- Effects of ultraviolet modification on the gating energetics of cyclic nucleotide-gated channels.The Journal of general physiology · 2000Article
- Structural basis for ligand selectivity of heteromeric olfactory cyclic nucleotide-gated channels.Biophysical journal · 2000Article
- Coexpression of alpha and beta subunits of the rod cyclic GMP-gated channel restores native sensitivity to cyclic AMP: role of D604/N1201.Biophysical journal · 2000Article
- Gating by cyclic GMP and voltage in the alpha subunit of the cyclic GMP-gated channel from rod photoreceptors.The Journal of general physiology · 1999Article
- Mechanism of allosteric modulation of rod cyclic nucleotide-gated channels.The Journal of general physiology · 1999Article
- Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Tetracaine reports a conformational change in the pore of cyclic nucleotide-gated channels.The Journal of general physiology · 1997Article
- Subunit interactions in the activation of cyclic nucleotide-gated ion channels.Biophysical journal · 1996Article
- Subunit interactions in coordination of Ni2+ in cyclic nucleotide-gated channels.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Effects of cysteine modification on the activity of the cGMP-gated channel from retinal rods.The Journal of membrane biology · 1995Article
- Regulation of calcium-activated nonselective cation channel activity by cyclic nucleotides in the rat insulinoma cell line, CRI-G1.The Journal of membrane biology · 1995Article
- Nucleotide Regulation of a calcium-activated cation channel in the rat insulinoma cell line, CRI-G1.The Journal of membrane biology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single channels are observed after incorporation of native vesicles from bovine rod outer segment membranes into planar lipid bilayers. The activity of a single channel in the presence of cGMP is compared to that induced by the analog 8-bromo-cGMP and by cAMP. At +80 mV, K0.5 is about 3 microM for 8Br-cGMP, 18 microM for cGMP and 740 microM for cAMP. In cAMP, the amplitude of the current is smaller than in cGMP or 8Br-cGMP and depends on the filter cut-off frequency. The open/closed transition rates of the channel are slightly slower with 8Br-cGMP than with cGMP while they are 5 to 10 times faster with cAMP. Addition of Ni2+ ions to either cGMP or cAMP increases the open probability: the open/closed transition rates and amplitude of the current in cAMP are then comparable to those in cGMP. A dual effect of the addition of cAMP on the cGMP- or 8Br-cGMP-dependent activity previously reported (Furman, R.E., Tanaka, J.C. 1989. Biochemistry 28:2785-2788) is observed with a single channel: addition of subthreshold cAMP concentrations to cGMP (or to 8Br-cGMP) markedly increases Po; addition of cAMP concentrations higher than about 70 microM progressively accelerates the kinetics and reduces the amplitude to values observed in cAMP alone. The results are discussed in relation with the model previously proposed to account for the existence of four current levels (Ildefonse, M., Bennett, N. 1991. J. Membrane Biol. 123:133-147).
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