ReviewRespiratory research2003
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry.
Review in Respiratory research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Fibroblast Growth Factors in Lung Development and Regeneration: Mechanisms and Therapeutic Potential.Cells · 2025Review
- Alteration in branching morphogenesis via YAP/TAZ in fibroblasts of fetal lungs in an LPS-induced inflammation model.Molecular medicine (Cambridge, Mass.) · 2023Article
- Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung.Frontiers in cell and developmental biology · 2021Article
- Oral Primo-Colonizing Bacteria Modulate Inflammation and Gene Expression in Bronchial Epithelial Cells.Microorganisms · 2020Article
- Overview of Lung Development in the Newborn Human.Neonatology · 2017Review
- Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.The American journal of pathology · 2016Article
- Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.Respiratory research · 2016Article
- Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.American journal of respiratory cell and molecular biology · 2016Article
- Secreted phosphoprotein 1 is a determinant of lung function development in mice.American journal of respiratory cell and molecular biology · 2014Article
- Pulmonary FGF-18 gene expression is downregulated during the canalicular-saccular stages in nitrofen-induced hypoplastic lungs.Pediatric surgery international · 2013Article
- HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.The European respiratory journal · 2013Article
- Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.PloS one · 2012Article
- Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Genetic influences on asthma susceptibility in the developing lung.American journal of respiratory cell and molecular biology · 2010Article
- Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis.The European respiratory journal · 2010Article
- Cited2 is required for fetal lung maturation.Developmental biology · 2008Article
- Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.Developmental biology · 2008Article
- Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.Molecular systems biology · 2007Article
- Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice.Pediatric research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung morphogenesis is stereotypic, both for lobation and for the first several generations of airways, implying mechanistic control by a well conserved, genetically hardwired developmental program. This program is not only directed by transcriptional factors and peptide growth factor signaling, but also co-opts and is modulated by physical forces. Peptide growth factors signal within repeating epithelial-mesenchymal temporospatial patterns that constitute morphogenetic centers, automatically directing millions of repetitive events during both stereotypic branching and nonstereotypic branching as well as alveolar surface expansion phases of lung development. Transduction of peptide growth factor signaling within these centers is finely regulated at multiple levels. These may include ligand expression, proteolytic activation of latent ligand, ligand bioavailability, ligand binding proteins and receptor affinity and presentation, receptor complex assembly and kinase activation, phosphorylation and activation of adapter and messenger protein complexes as well as downstream events and cross-talk both inside and outside the nucleus. Herein we review the critical Sonic Hedgehog, Fibroblast Growth Factor, Bone Morphogenetic Protein, Vascular Endothelial Growth Factor and Transforming Growth Factorbeta signaling pathways and propose how they may be functionally coordinated within compound, highly regulated morphogenetic gradients that drive first stereotypic and then non-stereotypic, automatically repetitive, symmetrical as well as asymmetrical branching events in the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.