ArticleJournal of neuro-oncology2003
Characterization of 9L glioma model of the Wistar rat.
Article in Journal of neuro-oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- A brain cancer microtissue model for studying tumor cell and neural cell interactions.Scientific reports · 2025Article
- Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research.Journal of neuropathology and experimental neurology · 2022Review
- Longitudinal evaluation of tumor microenvironment in rat focal brainstem glioma using diffusion and perfusion MRI.Journal of magnetic resonance imaging : JMRI · 2019Article
- Brain tumors disrupt the resting-state connectome.NeuroImage. Clinical · 2018Article
- Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent.BioMed research international · 2018Article
- Next-GenerationFrontiers in oncology · 2018Review
- Characterization of the distribution, retention, and efficacy of internal radiation ofJournal of neuro-oncology · 2017Article
- Evans blue nanocarriers visually demarcate margins of invasive gliomas.Drug delivery and translational research · 2015Article
- Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.ACS nano · 2015Article
- Characterization of the 9L gliosarcoma implanted in the Fischer rat: an orthotopic model for a grade IV brain tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A tubulin binding peptide targets glioma cells disrupting their microtubules, blocking migration, and inducing apoptosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- The 9L(LUC)/Wistar rat glioma model is not suitable for immunotherapy.Neural regeneration research · 2012Article
- The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo.European journal of nuclear medicine and molecular imaging · 2012Article
- Review
- In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI.Magnetic resonance in medicine · 2010Article
- Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.Journal of neuro-oncology · 2009Review
- Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells.Brain pathology (Zurich, Switzerland) · 2009Article
- Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2008Article
- Rejection of RG-2 gliomas is mediated by microglia and T lymphocytes.Journal of neuro-oncology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to develop and characterize solid brain tumors in Wistar rats, which could be used in investigations concerning the molecular mechanisms that lay beneath the genesis of the gliomas as well as in the testing of curative potentials of various therapeutics. The tumors were induced by intracerebral inoculation of 9L glioma cells and characterized by morphometrical, histological and immunohistochemical analysis after 7, 14 and 21 postimplantation days. Immunohistochemical characterization included detection of the nuclear antigene Ki-67 as the proliferative cell marker, GFAP as a tracer of reactive gliosis surrounding the tumor mass, and CD4/CD8 and ED1 antigens, as markers of the immunological response. Our results showed that after 7 days all experimental animals developed solid, well-circumcised tumors, which were clearly separated from the surrounding brain tissue. Tumors showed progressive growth from the 7th to the 21st day despite the observed immunological response starting after 14 days. Histologically tumors were hypercellular with neovascularization and necrosis. These results indicate that reproducible morphometric evaluation can be performed on 9L tumors growing in immunocompetent Wistar rats, enabling its use as an animal tumor model for the evaluation of various therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.