ArticlePflugers Archiv : European journal of physiology1992
Nuclear ion channels in cardiac myocytes.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3.The Journal of biological chemistry · 2015Article
- The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.The Journal of physiology · 2000Article
- Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines.Biophysical journal · 2000Article
- Dendrimer-assisted patch-clamp sizing of nuclear pores.Pflugers Archiv : European journal of physiology · 2000Article
- Calcium, ATP and nuclear pore channel gating.Pflugers Archiv : European journal of physiology · 2000Article
- Nuclear hourglass technique: an approach that detects electrically open nuclear pores in Xenopus laevis oocyte.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Single-channel kinetics, inactivation, and spatial distribution of inositol trisphosphate (IP3) receptors in Xenopus oocyte nucleus.The Journal of general physiology · 1997Article
- Reconstitution of ionic channels from inner and outer membranes of mammalian cardiac nuclei.Biophysical journal · 1996Article
- Patch clamp and atomic force microscopy demonstrate TATA-binding protein (TBP) interactions with the nuclear pore complex.The Journal of membrane biology · 1995Article
- The ion channel behavior of the nuclear pore complex.The Journal of membrane biology · 1995Article
- Patch clamp detection of transcription factor translocation along the nuclear pore complex channel.The Journal of membrane biology · 1995Article
- Nuclear electrophysiology.The Journal of membrane biology · 1994Review
- Open states of nuclear envelope ion channels in cardiac myocytes.The Journal of membrane biology · 1994Article
- Restricted ion flow at the nuclear envelope of cardiac myocytes.Biophysical journal · 1993Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The paradigm that nucleocytoplasmic transport of ions occurs without a diffusional barrier has been challenged by the recent demonstration with patch-clamp techniques of the existence of ion channels in the nuclear envelope of murine zygotes and hepatocytes. This report demonstrates the existence of nuclear ion channels (NIC) in murine ventricular cardiac myocytes. NIC conductance (gamma), calculated from current histogram peaks, was 106-532 pS at 22-36 degrees C. In nucleus-attached patches, replacement of cytoplasmic K+ with Na+ reduced NIC activity within 30 s, suggesting that intranuclear-delimited mechanisms mediate this phenomenon. In excised, inside-out patches K+ was as permeable as Na+ through NIC. NIC activity was observed in 0-4 mM Mg2+ and/or ATP2-, with or without 0-1 mM Ca2+, indicating a minor direct role of these ions. However, in non-responsive excised inside-out patches, NIC activity appeared when the catalytic subunit of the cAMP-dependent protein kinase was applied to the nucleoplasmic side of the patch, in the presence of Mg2+ and ATP2-, indicating an important role for phosphorylation-dependent process(es) in NIC function--an observation supported by the depressing effects of protein kinase inhibitor on responsive NIC. The concept that nucleopore complexes are solely responsible for nucleocytoplamic transport leads to the speculation that these structures are the physical substrate for NIC.
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