ReviewThe Journal of clinical investigation2003
Arginase: marker, effector, or candidate gene for asthma?
Review in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Recent understanding of immunometabolic remodeling in pulmonary macrophages: homeostasis, chronic respiratory diseases, and therapeutic targeting.Frontiers in pharmacology · 2026Review
- Macrophage Immunometabolism in Pulmonary Homeostasis and Chronic Lung Diseases.International journal of biological sciences · 2025Review
- Tranglutaminase 2 contributes to the asthmatic inflammation by modulating activation of alveolar macrophages.Immunity, inflammation and disease · 2021Article
- Macrophage metabolic reprogramming during chronic lung disease.Mucosal immunology · 2021Review
- Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.The Indian journal of medical research · 2018Article
- Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells.PLoS pathogens · 2015Article
- Article
- Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections.Mucosal immunology · 2014Review
- Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Caveolin-1 knockout mice exhibit airway hyperreactivity.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Nitric oxide metabolism in asthma pathophysiology.Biochimica et biophysica acta · 2011Review
- Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Journal of biomedical research · 2011Article
- Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease.American journal of hematology · 2011Article
- Article
- Article
- Macrophages: regulators of sex differences in asthma?American journal of respiratory cell and molecular biology · 2010Article
- L-arginine deprivation impairs Leishmania major-specific T-cell responses.European journal of immunology · 2009Article
- Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.PLoS neglected tropical diseases · 2009Article
- Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.Journal of leukocyte biology · 2009Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.