ArticleBritish journal of pharmacology2003
Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
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- Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields.Journal of cancer research and clinical oncology · 2021Article
- Reduced electron transport chain complex I protein abundance and function in Mfn2-deficient myogenic progenitors lead to oxidative stress and mitochondria swelling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
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- A sex difference in oxidative stress and behavioral suppression induced by ethanol withdrawal in rats.Behavioural brain research · 2016Article
- Mitochondrial Cyclophilin D as a Potential Therapeutic Target for Ischemia-Induced Facial Palsy in Rats.Cellular and molecular neurobiology · 2015Article
- Mitochondrial targeted peptides for cancer therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Molecular cancer therapeutics · 2014Article
- Schizophrenia induces oxidative stress and cytochrome C release in isolated rat brain mitochondria: a possible pathway for induction of apoptosis and neurodegeneration.Iranian journal of pharmaceutical research : IJPR · 2014Article
- 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway.British journal of pharmacology · 2013Article
- The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity.Neurobiology of disease · 2012Article
- Inhibition of axonal transport caused by tert-butyl hydroperoxide in cultured mouse dorsal root ganglion neurons.Journal of molecular neuroscience : MN · 2011Article
- Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies.Biomarkers in medicine · 2010Review
- Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid beta.Biochimica et biophysica acta · 2010Review
- Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.British journal of pharmacology · 2009Article
- Superoxide dismutases: a physiopharmacological update.Journal of physiology and biochemistry · 2009Review
- Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function.Antioxidants & redox signaling · 2009Review
- Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.The Journal of biological chemistry · 2008Article
- G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.Molecular and cellular biology · 2007Article
- Stroke pathophysiology: management challenges and new treatment advances.Journal of physiology and biochemistry · 2007Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1 In this study, we have used isolated brain mitochondria to investigate the effects of superoxide anions (O(2)(-)) on mitochondrial parameters related to apoptosis, such as swelling, potential, enzymatic activity, NAD(P)H, cytochrome c release, and caspase activity. 2 Addition of the reactive oxygen species (ROS) generator KO(2) produced brain mitochondrial swelling, which was blocked by cyclosporin A (CSA), and which was Ca(2+) independent. 3 Calcium induced mitochondrial swelling only at high concentrations and in the presence of succinate. This correlated with the increase in O(2)(-) production detected with hydroethidine in mitochondrial preparations exposed to Ca(2+) and the fact that ROS were required for Ca(2+)-induced mitochondrial swelling. 4 Superoxide anions, but not Ca(2+), decreased citrate synthase and dehydrogenase enzymatic activities and dropped total mitochondrial NAD(P)H levels. 5 Calcium, but not O(2)(-), triggered a rapid loss of mitochondrial potential. Calcium-induced Deltapsi(m) dissipation was inhibited by Ruthenium Red, but not by CSA. 6 Calcium- and superoxide-induced mitochondrial swelling released cytochrome c and increased caspase activity from isolated mitochondria in a CS A-sensitive manner. 7 In summary, superoxide potently triggers mitochondrial swelling and the release of proteins involved in activation of postmitochondrial apoptotic pathways in the absence of mitochondrial depolarization.
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