ReviewPediatric nephrology (Berlin, Germany)2003
Role of extracellular matrix in kidney development and repair.
Review in Pediatric nephrology (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Review
- Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025Review
- 3D Bioprinting for Engineered Tissue Constructs and Patient-Specific Models: Current Progress and Prospects in Clinical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Role of extracellular matrix components and structure in new renal modelsFrontiers in physiology · 2022Review
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- Glomerular endothelial cell heterogeneity in Alport syndrome.Scientific reports · 2020Article
- Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.Journal of cell science · 2019Article
- Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney.Tissue engineering and regenerative medicine · 2019Article
- A Photo-Crosslinkable Kidney ECM-Derived Bioink Accelerates Renal Tissue Formation.Advanced healthcare materials · 2019Article
- Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel.Journal of visualized experiments : JoVE · 2018Article
- Article
- Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence.Tissue engineering. Part A · 2016Article
- Article
- Current Bioengineering Methods for Whole Kidney Regeneration.Stem cells international · 2015Review
- A self-avoidance mechanism in patterning of the urinary collecting duct tree.BMC developmental biology · 2014Article
- Regeneration and bioengineering of the kidney: current status and future challenges.Current urology reports · 2014Review
- Article
- Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds.Journal of the American Society of Nephrology : JASN · 2009Article
- MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development.Journal of the American Society of Nephrology : JASN · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular matrix (ECM) molecules and their receptors exert a dynamic role in cell-matrix interactions during kidney development and repair processes. They provide a physical substratum for the spatial organization of the cells, but also regulate cell growth and proliferation by interacting with growth factors. In addition, they can regulate signal transduction pathways by binding to integrins or by modulating the activity of signaling molecules such as Wnts. ECM and ECM-related molecules control multiple (if not all) steps of kidney development, including ureteric bud branching morphogenesis, mesenchymal condensation, nephron formation, terminal differentiation of renal tubules, and glomerular basement membrane assembly. Their role still needs to be better documented in renal repair. The emergence of conditionally mutated mice for basement membrane components will provide a useful tool to demonstrate further the involvement of ECM and ECM-related proteins in development and repair.
Indexed as
Identifiers
12811645What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.