ArticleHuman genetics2003
Comparison of strategies for selecting single nucleotide polymorphisms for case/control association studies.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- The anti-Müllerian hormone gene's second exon is associated with the reproductive performance of Jinghai Yellow chickens.Archives animal breeding · 2021Article
- Association betweenArchives animal breeding · 2019Article
- Validation of PDE9A Gene Identified in GWAS Showing Strong Association with Milk Production Traits in Chinese Holstein.International journal of molecular sciences · 2015Article
- Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis.Clinical and experimental medicine · 2013Article
- Single nucleotide polymorphism in the STAT5b gene is associated with body weight and reproductive traits of the Jinghai Yellow chicken.Molecular biology reports · 2012Article
- Association of FATP1 gene polymorphisms with chicken carcass traits in Chinese meat-type quality chicken populations.Molecular biology reports · 2010Article
- Polymorphism of chicken myocyte-specific enhancer-binding factor 2A gene and its association with chicken carcass traits.Molecular biology reports · 2010Article
- STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement.European journal of clinical investigation · 2009Article
- Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens.BMC genetics · 2009Article
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement.Human genetics · 2009Article
- STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement.PLoS medicine · 2009Article
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement.European journal of epidemiology · 2009Review
- Comparison of tagging single-nucleotide polymorphism methods in association analyses.BMC proceedings · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely believed that a subset of single nucleotide polymorphisms (SNPs) is able to capture the majority of the information for genotype-phenotype association studies that is contained in the complete compliment of genetic variations. The question remains, how does one select that particular subset of SNPs in order to maximize the power of detecting a significant association? In this study, we have used a simulation approach to compare three competing methods of site selection: random selection, selection based on pair-wise linkage disequilibrium, and selection based on maximizing haplotype diversity. The results indicate that site selection based on maximizing haplotype diversity is preferred over random selection and selection based on pair-wise linkage disequilibrium. The results also indicate that it is more prudent to increase the sample size to improve a study's power than to continuously increase the number of SNPs. These results have direct implications for designing gene-based and genome-wide association studies.
Indexed as
Identifiers
12811538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.