ArticleRheumatology international2004
Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitis.
Article in Rheumatology international, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Environmental and Genetic Determinants of Ankylosing Spondylitis.International journal of molecular sciences · 2024Review
- Local delivery of gaseous signaling molecules for orthopedic disease therapy.Journal of nanobiotechnology · 2023Review
- Relationship between diet, oxidative stress, and inflammation in ankylosing spondylitis.Archives of rheumatology · 2022Article
- Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction.Diagnostics (Basel, Switzerland) · 2021Article
- Does whole body vibration exercise improve oxidative stress markers in women with fibromyalgia?Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method.Northern clinics of Istanbul · 2019Article
- Decreased Oxidative Stress in Male Patients with Active Phase Ankylosing Spondylitis Who Underwent Whole-Body Cryotherapy in Closed Cryochamber.Oxidative medicine and cellular longevity · 2018Article
- Evaluation of auditory and cochlear functions in ankylosing spondylitis patients according to the site of involvement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors.Oxidative medicine and cellular longevity · 2017Article
- Thiol/disulfide homeostasis in patients with ankylosing spondylitis.Bosnian journal of basic medical sciences · 2016Article
- Oxidative stress and related factors in patients with ankylosing spondylitis.European journal of rheumatology · 2016Article
- Evaluation of paraoxonase and arylesterase activities in Egyptian patients with ankylosing spondylitis.Rheumatology international · 2013Article
- Trace element levels in patients with familial mediterranean Fever.The Eurasian journal of medicine · 2011Article
- The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome.Clinical rheumatology · 2011Article
- Pathophysiology and antioxidant status of patients with fibromyalgia.Rheumatology international · 2011Review
- The effect of anti-TNF agent on oxidation status in patients with ankylosing spondylitis.Clinical rheumatology · 2010Article
- Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients.Clinics (Sao Paulo, Brazil) · 2010Article
- Serum oxidative-antioxidative status in patients with ankylosing spondilitis.Rheumatology international · 2007Article
- Erythrocyte oxidant/antioxidant status in essential hyperhidrosis.Molecular and cellular biochemistry · 2006Article
- Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide.Rheumatology international · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, serum antioxidant and oxygen derived free radical status of patients with ankylosing spondylitis (AS) was investigated and compared with that of age- and sex-matched healthy controls. The relationship of these parameters to disease activity indices was also examined. Thirty patients with AS not currently under disease-modifying antirheumatic drug (DMARD) treatment (e.g., sulfasalazine or methotrexate) (15 active and 15 inactive) and 16 age- and sex-matched healthy controls were included in the study. Catalase (EC 1.11.1.6), total (Cu-Zn and Mn) superoxide dismutase (SOD) (EC 1.15.1.1) activities, and malondialdehyde (MDA), nitrite (NO(2)(-)), and nitrate (NO(3)(-)) levels as indices of nitric oxide (NO) production were evaluated using appropriate methods. There was no statistically significant difference found in SOD activity or NO and MDA levels between active and inactive patients. Inactive patients showed no significant difference in all the measured oxidant/antioxidant parameters when compared to healthy controls. Active patients had significantly higher levels of MDA and catalase enzyme activity ( P=0.002 and P=0.007, respectively). There was no significant correlation between oxidant/antioxidant parameters and disease activity, C-reactive protein, erythrocyte sedimentation rate, or Bath Ankylosing Spondylitis Disease Activity Index (CRP, ESR, or BASDAI) in either group, except catalase enzyme activity, which had a significant correlation with CRP and ESR levels in active patients ( r=0.69 and P=0.004, r=0.52 and P=0.04, respectively). Our results indicate that oxidative stress and lipid peroxidation are accelerated in untreated patients with active AS. Serum catalase activity may be closely related to disease activity. In this regard, we underscore the likely benefit of some therapeutic interventions including high-potential antioxidants that will potentiate the antioxidant defense mechanism and reduce peroxidation in the management of AS.
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