ArticleInternational journal of colorectal disease2003
Prognostic significance of Bcl-2 and p53 expression in gastric cancer.
Article in International journal of colorectal disease, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-γ-linolenic acid peroxidation pattern in lung cancer.Free radical biology & medicine · 2021Article
- MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/Gastroenterology research and practice · 2020Article
- IKKε and TBK1 expression in gastric cancer.Oncotarget · 2017Article
- Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer.Virchows Archiv : an international journal of pathology · 2016Article
- Comparison between Resectable Helicobacter pylori-Negative and -Positive Gastric Cancers.Gut and liver · 2016Article
- Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review).Oncology letters · 2015Article
- Pathogenetic mechanisms in gastric cancer.World journal of gastroenterology · 2014Review
- Helicobacter pylori and Molecular Markers as Prognostic Indicators for Gastric Cancer in Korea.Journal of cancer prevention · 2014Article
- Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells.Cancer biology & therapy · 2013Article
- CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line.World journal of surgical oncology · 2013Article
- The prognostic significance of the increase in the serum M30 and M65 values after chemotherapy and relationship between these values and clinicopathological factors in patients with advanced gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors.Virchows Archiv : an international journal of pathology · 2011Article
- Genomic and genetic alterations influence the progression of gastric cancer.World journal of gastroenterology · 2011Review
- The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.PloS one · 2011Article
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7 authors.
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Abstract
BACKGROUND AND
aimsApoptosis regulates cell death and influences cell proliferation and therefore may play an important role in development or growth of various malignant tumors. The Bcl-2 and p53 are closely linked in the regulation of apoptosis. We investigated the prognostic significance of Bcl-2 and p53 expression in patients with gastric cancer. PATIENTS AND
methodsImmunohistochemistry was used to study Bcl-2 and p53 expression in 308 consecutive patients with gastric cancer.
resultsBcl-2 expression was positive in 39 patients (12.7%) and showed a significant negative correlation with depth of invasion and lymph node metastasis. p53 expression was observed in 105 patients (34.1%) and was significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and intestinal type. Patients with Bcl-2(+) tumors showed a trend to better 5-year survival rate (81%) than those with Bcl-2(-) negative tumors (71%). The 5-year survival rate in p53 positive cases (60%) was significantly lower than that in p53-negative cases (78%). In addition, p53 expression showed a significantly poorer prognosis in both diffuse and intestinal types. In multivariate analysis restricted to patients with R0 resection p53 expression was an independent prognostic factor (relative risk: 2.063). In combined assessment of p53 and Bcl-2 expression the group with p53(+)/Bcl-2(-) tumors showed significantly worse 5-year survival (57%) than the other groups, while best survival was seen in the group with p53(+)/Bcl-2(+) tumors (100%).
conclusionp53 expression is an unfavorable prognostic factor in gastric cancer. Bcl-2 expression may have possible prognostic value when combined with p53 expression.
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