ArticleImmunogenetics2003
Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- A meta-analysis on the association between three promoter variants of TNF-α and Crohn's disease.Molecular biology reports · 2012Pooled it
- Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis.European journal of human genetics : EJHG · 2011Pooled it
- Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease.Inflammatory bowel diseases · 2021Article
- Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets.PeerJ · 2021Article
- TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.Molecular biology reports · 2020Article
- Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Association of tumor necrosis factor-α and -β gene polymorphisms in inflammatory bowel disease.Journal of inflammation research · 2016Article
- Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.World journal of gastrointestinal pathophysiology · 2014Review
- Association of Tumor Necrosis Factor Alpha Gene Polymorphisms with Inflammatory Bowel Disease in Iran.Iranian journal of public health · 2014Article
- C-Reactive Protein Gene Polymorphisms and the Risk of Atrial Fibrillation in a Chinese Population in Taiwan.Acta Cardiologica Sinica · 2013Article
- The TNF-α -308 polymorphism may affect the severity of Crohn's disease.Clinics (Sao Paulo, Brazil) · 2011Article
- Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk.World journal of gastroenterology · 2008Article
- Genetic determinants of C-reactive protein.Current atherosclerosis reports · 2007Review
- Microheterogeneity of acute phase proteins in patients with ulcerative colitis.World journal of gastroenterology · 2006Article
- A subgroup of first-degree relatives of Crohn's disease patients shows a profile of inflammatory markers in the blood which is more typical of Crohn's disease patients than of normal individuals.Mediators of inflammation · 2006Article
- Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms.Mediators of inflammation · 2004Article
- Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.Genes and immunityArticle
- TNF-alpha gene polymorphisms in Iranian Azari Turkish patients with inflammatory bowel diseases.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study was to determine the prevalence of the tumor necrosis factor alpha (TNF-alpha) promoter polymorphisms at positions -238 and -308, and to measure the serum CRP levels in CD and UC patients and in a healthy population. The TNF-alpha gene polymorphisms were determined by the PCR-RFLP method. Samples of 74 CD and 50 UC patients and 138 healthy Hungarian volunteers were examined. The G-->A substitution at position -308 (designated the TNF2 allele) was significantly less frequent among IBD patients than in the control group (P=0.0009); 15% of the CD patients and 18% of the UC patients carried the mentioned allele, which was significantly less frequent compared with the healthy population (33%, P=0.0035 and P=0.036, respectively). No difference in the G-->A substitution at position -238 was observed. We found the median CRP levels to be significantly higher in the active phase of the disease than in the inactive phase among the -308A allele carriers (P=0.002), while this difference was not significant when the CRP levels in the active and inactive phases were compared among the -308GG homozygous patients (P=0.084). The decreased frequency of the TNF2 allele (known to be associated with elevated TNF-alpha production) in IBD may determine the severity of IBD through its interaction with plasma CRP levels, and may modify the pathogenesis of this chronic inflammatory disease.
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