ArticleImmunogenetics2003
MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed, 320 citations in OpenAlex.
- Farmed Escapees Threaten MHC Diversity in Wild Atlantic Salmon.Evolutionary applications · 2026Article
- Reverse vaccinology and immunoinformatics-driven design of a multiepitope vaccine candidate againstFrontiers in bioinformatics · 2026Article
- Insights into mucosal and systemic immune responses of African catfish, Clarias gariepinus, to chilodonellosis: A natural infection study.Journal of fish biology · 2025Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide loading of MHC molecules.Current opinion in immunology · 2022Review
- MHC class I-α population differentiation in a commercial fish, the European sea bass (Dicentrarchus labrax).Animal genetics · 2022Article
- Article
- Whole-genome association study searching for QTL for Aeromonas salmonicida resistance in rainbow trout.Scientific reports · 2021Article
- Challenges and Solutions to Viral Diseases of Finfish in Marine Aquaculture.Pathogens (Basel, Switzerland) · 2021Review
- Fate of MHCII in salmonids following 4WGD.Immunogenetics · 2021Article
- MHC class I evolution; from Northern pike to salmonids.BMC ecology and evolution · 2021Article
- Comparison of Gene Expression Between Resistant and Susceptible Families Against VPFrontiers in genetics · 2021Article
- Review
- Transcriptome sequencing and histology reveal dosage compensation in the liver of triploid pre-smolt Atlantic salmon.Scientific reports · 2020Article
- Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections.Current biology : CB · 2020Article
- Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance toGenes · 2020Article
- An Illumina approach to MHC typing of Atlantic salmon.Immunogenetics · 2020Review
- Combining Multiple Approaches and Models to Dissect the Genetic Architecture of Resistance to Infections in Fish.Frontiers in genetics · 2020Review
- QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon.The Journal of heredity · 2019Article
- Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?G3 (Bethesda, Md.) · 2019Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have yet addressed the functional aspects of MHC molecules in fish. To lay the foundation for this, we evaluated the association between disease resistance and MHC class I and class II polymorphism in Atlantic salmon. Standardized disease challenge trials were performed on a semi-wild Atlantic salmon population with subsequent MHC typing and statistical analysis. The pathogens employed were infectious salmon anaemia virus (ISAV) causing infectious salmon anaemia and the Aeromonas salmonicida bacteria causing furunculosis. The material consisted of 1,182 Atlantic salmon from 33 families challenged with A. salmonicida and 1,031 Atlantic salmon from 25 families challenged with ISAV. We found highly significant associations between resistance towards infectious diseases caused by both pathogens and MH class I and class II polymorphism in Atlantic salmon. The observed associations were detected due to independently segregating MH class I and class II single loci, and inclusion of a large number of fish allowing an extensive statistical analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.