ArticleProceedings of the National Academy of Sciences of the United States of America2003
Differential proteasomal processing of hydrophobic and hydrophilic protein regions: contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.PLoS pathogens · 2012Trial
- Development of multivalent vaccine targeting M segment of Crimean Congo Hemorrhagic Fever Virus (CCHFV) using immunoinformatic approaches.Saudi journal of biological sciences · 2022Article
- Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source outbreak.Scientific reports · 2018Article
- Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B.PLoS pathogens · 2018Article
- Immunoinformatics and epitope prediction in the age of genomic medicine.Genome medicine · 2015Review
- The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.European journal of immunology · 2015Article
- Review
- Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles: A Step towards Designing CTL Based HIV-1 Vaccine.Advances in virology · 2014Review
- Computational prediction of cleavage using proteasomal in vitro digestion and MHC I ligand data.Journal of Zhejiang University. Science. B · 2013Article
- Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.PLoS biology · 2013Article
- HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses.PloS one · 2012Article
- Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.PLoS computational biology · 2012Article
- Bacteria modulate the CD8+ T cell epitope repertoire of host cytosol-exposed proteins to manipulate the host immune response.PLoS computational biology · 2011Article
- The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.PLoS pathogens · 2011Article
- Signal peptides and trans-membrane regions are broadly immunogenic and have high CD8+ T cell epitope densities: Implications for vaccine development.Molecular immunology · 2011Article
- Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire.Journal of virology · 2011Article
- Article
- The distribution of CTL epitopes in HIV-1 appears to be random, and similar to that of other proteomes.BMC evolutionary biology · 2009Article
- Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.PloS one · 2007Article
- Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.Journal of virology · 2004Article
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9 authors.
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Abstract
HIV proteins contain a multitude of naturally processed cytotoxic T lymphocyte (CTL) epitopes that concentrate in clusters. The molecular basis of epitope clustering is of interest for understanding HIV immunogenicity and for vaccine design. We show that the CTL epitope clusters of HIV proteins predominantly coincide with hydrophobic regions, whereas the noncluster regions are predominantly hydrophilic. Analysis of the proteasomal degradation products of full-length HIV-Nef revealed a differential sensitivity of cluster and noncluster regions to proteasomal processing. Compared with the epitope-scarce noncluster regions, cluster regions are digested by proteasomes more intensively and with greater preference for hydrophobic P1 residues, resulting in substantially greater numbers of fragments with the sizes and COOH termini typical of epitopes and their precursors. Indeed, many of these fragments correspond to endogenously processed Nef epitopes and/or their potential precursors. The results suggest that differential proteasomal processing contributes importantly to the clustering of CTL epitopes in hydrophobic regions.
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