ArticleProceedings of the National Academy of Sciences of the United States of America2003
Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.
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154 citing papers in PubMed.
- In silico characterization of melanoma-derived mouse lncRNA Gm26982 and comparative analyses with human ortholog.Molecular genetics and genomics : MGG · 2026Article
- The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice.Molecular biology and evolution · 2025Article
- Random, fragile, or correlated: Mechanisms of synteny decay in mammals.bioRxiv : the preprint server for biology · 2025Article
- The genomic imprint of chromosomal inversions and demographic history in island populations of deer mice.bioRxiv : the preprint server for biology · 2025Article
- Domain-Shuffling in the Evolution of Cyclostomes and Gnathostomes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Highlighting chromosomal rearrangements of five species of Galliformes (Domestic fowl, Common and Japanese quail, Barbary and Chukar partridge) and the Houbara bustard, an endangered Otidiformes: banding cytogenetic is a powerful tool.Comparative cytogenetics · 2024Article
- Review
- Rearrangement Events on Circular Genomes.Bulletin of mathematical biology · 2023Article
- Chromosomal conservatism vs chromosomal megaevolution: enigma of karyotypic evolution in Lepidoptera.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Review
- Genes that are Used Together are More Likely to be Fused Together in Evolution by Mutational Mechanisms: A Bioinformatic Test of the Used-Fused Hypothesis.Evolutionary biology · 2023Article
- Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants.Animals : an open access journal from MDPI · 2022Review
- Evolution of the ancestral mammalian karyotype and syntenic regions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evolutionary breakpoint regions and chromosomal remodeling in Harttia (Siluriformes: Loricariidae) species diversification.Genetics and molecular biology · 2022Article
- Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022Review
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- Inversion breakpoints and the evolution of supergenes.Molecular ecology · 2021Review
- Article
- A new duck genome reveals conserved and convergently evolved chromosome architectures of birds and mammals.GigaScience · 2021Article
- Scalable multiple whole-genome alignment and locally collinear block construction with SibeliaZ.Nature communications · 2020Article
94 more citing papers are in PubMed but not listed here.
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Abstract
The human and mouse genomic sequences provide evidence for a larger number of rearrangements than previously thought and reveal extensive reuse of breakpoints from the same short fragile regions. Breakpoint clustering in regions implicated in cancer and infertility have been reported in previous studies; we report here on breakpoint clustering in chromosome evolution. This clustering reveals limitations of the widely accepted random breakage theory that has remained unchallenged since the mid-1980s. The genome rearrangement analysis of the human and mouse genomes implies the existence of a large number of very short "hidden" synteny blocks that were invisible in the comparative mapping data and ignored in the random breakage model. These blocks are defined by closely located breakpoints and are often hard to detect. Our results suggest a model of chromosome evolution that postulates that mammalian genomes are mosaics of fragile regions with high propensity for rearrangements and solid regions with low propensity for rearrangements.
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