ArticleThe Journal of experimental medicine2003
Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk.International journal of biological sciences · 2024Article
- Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance.PLoS pathogens · 2023Article
- Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis.European journal of immunology · 2022Article
- Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.The Journal of biological chemistry · 2020Review
- Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy.Frontiers in immunology · 2020Article
- AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study.PloS one · 2020Article
- LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma.The Journal of experimental medicine · 2018Article
- Acyloxyacyl hydrolase modulates pelvic pain severity.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury.PLoS pathogens · 2017Article
- Toll-like receptor agonists promote prolonged triglyceride storage in macrophages.The Journal of biological chemistry · 2014Article
- Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Persistently active microbial molecules prolong innate immune tolerance in vivo.PLoS pathogens · 2013Article
- Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes.Innate immunity · 2012Article
- The metabolic serine hydrolases and their functions in mammalian physiology and disease.Chemical reviews · 2011Review
- The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin.Hepatology (Baltimore, Md.) · 2011Article
- ABCA1 promotes the efflux of bacterial LPS from macrophages and accelerates recovery from LPS-induced tolerance.Journal of lipid research · 2010Article
- Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo.The Journal of infectious diseases · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We describe here a previously unrecognized property of dendritic cells (DCs), the ability to deacylate the lipid A moiety of gram-negative bacterial LPSs. Both immature DCs of the XS52 cell line and bone marrow-derived DCs produce acyloxyacyl hydrolase, an enzyme that detoxifies LPS by selectively removing the secondary acyl chains from lipid A. Acyloxyacyl hydrolase expression decreased when DCs were incubated with IL-4, IL-1 beta, TNF alpha, and an agonistic CD40 antibody (maturation cocktail), and increased after treatment with LPS, CpG oligodeoxynucleotides, or a gram-positive bacterium (Micococcus luteus). Maturation cocktail treatment also diminished, whereas LPS treatment enhanced or maintained the cells' ability to kill Escherichia coli, deacylate LPS, and degrade bacterial protein. Enzymatic deacylation of LPS is an intrinsic, regulated mechanism by which DCs may modulate host responses to this potent bacterial agonist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.