ArticleMolecular psychiatry2003
Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.Journal of affective disorders · 2013Article
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder.PloS one · 2013Article
- Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.Biological psychiatry · 2012Article
- Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series.Bipolar disorders · 2012Article
- Article
- Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype.European journal of human genetics : EJHG · 2009Article
- Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia.Behavioral and brain functions : BBF · 2009Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.American journal of human genetics · 2007Article
- A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.Neuromolecular medicine · 2007Article
- Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Article
- Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22.Molecular psychiatry · 2005Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Bipolar (BP) disorder or manic depressive illness is a major psychiatric disorder for which numerous family, twin and adoption studies support a substantial genetic contribution. Recently, we reported the results of a genome-wide search for BP disorder susceptibility loci in 20 pedigrees. Suggestive evidence for linkage was found in this study at three markers on 13q, representing possibly two peaks separated by 18 cM. We have now collected a second set of 32 pedigrees segregating BP disorder and have tested for evidence of linkage to markers on human chromosome 13q. In this sample, we have replicated the linkage result in 13q32 at D13S154 (lod=2.29), the more proximal of the two original peaks. When all 52 pedigrees were combined, the multipoint maximum lod score peaked approximately 7 cM proximal to D13S154 (lod=3.40), with a second peak occurring between D13S225 and D13S796 (lod=2.58). There have been several other reports of significant linkage to both BP disorder and schizophrenia in this region of chromosome 13. These pedigrees provide additional evidence for at least one locus for BP disorder in 13q32, and are consistent with other reports of a possible genetic overlap between these disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.