ArticleMolecular psychiatry2003
Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Pooled it
- A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.Human molecular genetics · 2010Pooled it
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
- The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23.Molecular psychiatry · 2006Trial
- Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Molecular psychiatry · 2005Trial
- Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report.Journal of clinical laboratory analysis · 2023Article
- Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated byAntioxidants (Basel, Switzerland) · 2022Article
- Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.Cellular and molecular neurobiology · 2020Review
- Age dependent association of inbreeding with risk for schizophrenia in Egypt.Schizophrenia research · 2020Article
- Effect of chronic unpredictable stress on mice with developmental under-expression of the Ahi1 gene: behavioral manifestations and neurobiological correlates.Translational psychiatry · 2018Article
- Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia.Schizophrenia research · 2017Article
- Alterations in the expression of a neurodevelopmental gene exert long-lasting effects on cognitive-emotional phenotypes and functional brain networks: translational evidence from the stress-resilient Ahi1 knockout mouse.Molecular psychiatry · 2017Article
- Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population.PloS one · 2017Article
- Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.Molecular genetics & genomic medicine · 2016Article
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- The influence of AHI1 variants on the diagnosis and treatment outcome in schizophrenia.International journal of molecular sciences · 2015Article
- Neural mechanisms underlying stress resilience in Ahi1 knockout mice: relevance to neuropsychiatric disorders.Molecular psychiatry · 2014Article
- Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.PloS one · 2012Article
- Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample.PloS one · 2012Article
- Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study.PloS one · 2010Article
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a complex neuropsychiatric disorder to which an as-yet-unknown number of genes contribute, interacting with each other and the environment. Linkage analyses have implicated several chromosomal regions as harboring schizophrenia susceptibility loci although rarely at levels commensurate with proposed thresholds for genome-wide significance. We systematically recruited Arab Israeli families multiply affected with schizophrenia from the catchment area of a Regional Mental Health Center. Clinical diagnoses were established by semistructured interviews and all other available sources of information under narrow, core and broad categories. Using 350 microsatellite markers, spaced at an average of 10.3 cM, we performed an autosomal scan in 155 subjects from 21 families. Linkage analysis employed affects only, multipoint, nonparametric (model-free) and also parametric (dominant and recessive) approaches. We detected significant evidence for a schizophrenia susceptibility gene at chromosome 6q23 with a nonparametric LOD score (NPL) of 4.60 (P=0.000004) under the broad diagnostic category and a parametric LOD score of 3.33 (dominant model). Under the core diagnostic category the NPL was 4.29 (P=0.00001) and the LOD score 4.16 (dominant model). We also detected suggestive evidence for linkage at chromosome 10q24 under the broad diagnostic category (NPL 3.24, P=0.0008; heterogeneity LOD score, dominant model 2.65, alpha=0.82). Additionally, NPL scores >2.0 were observed at chromosome 2q37, 4p15-16, 7p22, 9q21-22 and 14q11.1-11.2. The linkage we detected at chromosome 6q23 fulfills the criteria for genome-wide significance and is located approximately midway between loci suggested by a previous significant report at chromosome 6q25 and findings located more centromerically at 6q21-22.
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