ArticleGenetics2003
False discovery rate in linkage and association genome screens for complex disorders.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
68 citing papers in PubMed.
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- Genomewide association for schizophrenia in the CATIE study: results of stage 1.Molecular psychiatry · 2008Trial
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- Identification and validation of a novel robust glioblastoma prognosis model based on bioinformatics.Heliyon · 2024Article
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- BMP-2 Induced Signaling Pathways and Phenotypes: Comparisons Between Senescent and Non-senescent Bone Marrow Mesenchymal Stem Cells.Calcified tissue international · 2022Article
- False discovery rate control in genome-wide association studies with population structure.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.Molecular psychiatry · 2021Article
- Status and prospects of genome-wide association studies in plants.The plant genome · 2021Review
- Simultaneous Enrichment Analysis of all Possible Gene-sets: Unifying Self-Contained and Competitive Methods.Briefings in bioinformatics · 2020Review
- Multi-resolution localization of causal variants across the genome.Nature communications · 2020Article
- Single-Gene Deletions Contributing to Loss of Heterozygosity inG3 (Bethesda, Md.) · 2019Article
- Data mining to understand health status preceding traumatic brain injury.Scientific reports · 2019Observational
- Gene hunting with hidden Markov model knockoffs.Biometrika · 2019Article
- Controlling the Rate of GWAS False Discoveries.Genetics · 2017Article
- P values: from suggestion to superstition.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.