ArticleImmunology2003
Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Medical oncology (Northwood, London, England) · 2010Trial
- Plant Metabolites as Potential Agents That Potentiate or Block Resistance Mechanisms Involving β-Lactamases and Efflux Pumps.International journal of molecular sciences · 2025Review
- Spatiotemporal control of immune responses with nucleic acid cocktail vaccine.Advanced therapeutics · 2024Article
- Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent againstSaudi journal of biological sciences · 2021Article
- Preferential Selection and Contribution of Non-Structural Protein 1 (NS1) to the Efficient Transmission of Panzootic Avian Influenza H5N8 Virus Clades 2.3.4.4A and B in Chickens and Ducks.Journal of virology · 2021Article
- A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Interferon-inducer antivirals: Potential candidates to combat COVID-19.International immunopharmacology · 2021Review
- Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic AsthmaFrontiers in pharmacology · 2021Article
- Evaluation of Berberine as an Adjunct to TB Treatment.Frontiers in immunology · 2021Article
- Article
- Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.Integrative medicine (Encinitas, Calif.) · 2020Review
- The status of and trends in the pharmacology of berberine: a bibliometric review [1985-2018].Chinese medicine · 2020Review
- Effect ofOxidative medicine and cellular longevity · 2019Article
- Anti-Inflammatory and Immunomodulatory Effects of Barberry (Oxidative medicine and cellular longevity · 2019Review
- Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.AMB Express · 2018Article
- Investigation of the Immunomodulatory effect of Berberis vulgaris on core-pulsed dendritic cell vaccine.BMC complementary and alternative medicine · 2016Article
- In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Protective effect of berberine chloride on Plasmodium chabaudi-induced hepatic tissue injury in mice.Saudi journal of biological sciences · 2015Article
- STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer.Cancer immunology research · 2014Article
- Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice.Biological research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we investigated whether berberine-mediated induction of interleukin-12 (IL-12) production in antigen-presenting cells could regulate a cytokine profile of antigen-primed CD4+ T helper (Th) cells. Pretreatment with berberine induced IL-12 production in both macrophages and dendritic cells, and significantly increased the levels of IL-12 production in lipopolysaccharide-stimulated macrophages and in CD40 ligand-stimulated dendritic cells. Importantly, berberine pretreatment of macrophages increased their ability to induce interferon-gamma (IFN-gamma) and reduced their ability to induce IL-4 in antigen-primed CD4+ T cells. Berberine did not influence the macrophage cell surface expression of the class II major histocompatibility complex molecule, the co-stimulatory molecules CD80 and CD86, and intracellular adhesion molecule-1. Addition of neutralizing anti-IL-12p40 monoclonal antibody to cultures of berberine-pretreated macrophages and CD4+ T cells restored IL-4 production in antigen-primed CD4+ T cells. The in vivo administration of berberine resulted in the enhanced induction of IL-12 production by macrophages when stimulated in vitro with lipopolysaccharide or heat-killed Listeria monocytogenes, leading to the inhibition of the Th type 2 cytokine profile (decreased IL-4 and increased IFN-gamma production) in antigen-primed CD4+ T cells. These findings may point to a possible therapeutic use of berberine or medicinal plants containing berberine in the Th type 2 cell-mediated immune diseases such as allergic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.