ArticlePlant physiology2003
Physiological and molecular assessment of altered expression of Hsc70-1 in Arabidopsis. Evidence for pleiotropic consequences.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 197 citations in OpenAlex.
- Genome-wide analysis of HSP70 family in Zygophyllum xanthoxylum and its heat stress response in Arabidopsis.Plant cell reports · 2026Article
- Heterologous expression of heat-resistant obscure (Hero) proteins enhances thermotolerance in plants.iScience · 2025Article
- Genome-Wide Identification and Expression Analysis of HSP70 Gene Family Under High-Temperature Stress in Lettuce (International journal of molecular sciences · 2024Article
- Insights into the Heat Shock Protein 70 (Hsp70) Family inPlants (Basel, Switzerland) · 2024Article
- The LpHsfA2-molecular module confers thermotolerance via fine tuning of its transcription in perennial ryegrass (Lolium perenne L.).Journal of integrative plant biology · 2024Article
- Physiological and transcriptomic analyses provide insight into thermotolerance in desert plant Zygophyllum xanthoxylum.BMC plant biology · 2023Article
- Exploration of the truncated cytosolic Hsp70 in plants - unveiling the diverse T1 lineage and the conserved T2 lineage.Frontiers in plant science · 2023Article
- Gain-of-function of the cytokinin response activator ARR1 increases heat shock tolerance inPlant signaling & behavior · 2022Article
- Regulation of heat shock proteins 70 and their role in plant immunity.Journal of experimental botany · 2022Review
- Molecular Bases of Heat Stress Responses in Vegetable Crops With Focusing on Heat Shock Factors and Heat Shock Proteins.Frontiers in plant science · 2022Review
- Biochemical aspects of seeds from Cannabis sativa L. plants grown in a mountain environment.Scientific reports · 2021Article
- Heat Shock Signaling in Land Plants: From Plasma Membrane Sensing to the Transcription of Small Heat Shock Proteins.Frontiers in plant science · 2021Review
- Central role of 70-kDa heat shock protein in adaptation of plants to drought stress.Cell stress & chaperones · 2020Article
- LsHSP70 is induced by high temperature to interact with calmodulin, leading to higher bolting resistance in lettuce.Scientific reports · 2020Article
- Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue.Frontiers in plant science · 2020Article
- Overexpression of Seagrass Nucleotide Exchange Factor GenePlant signaling & behavior · 2020Article
- Comparative transcriptome analysis reveals important roles of nonadditive genes in maize hybrid An'nong 591 under heat stress.BMC plant biology · 2019Article
- Increased fes1a thermotolerance is induced by BAG6 knockout.Plant molecular biology · 2019Article
- Insights from the molecular docking analysis of phytohormone reveal brassinolide interaction with HSC70 from Pennisetum glaucum.Bioinformation · 2019Article
- Two Arabidopsis Chloroplast GrpE Homologues Exhibit Distinct Biological Activities and Can Form Homo- and Hetero-Oligomers.Frontiers in plant science · 2019Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hsp70s function as molecular chaperones. The protective chaperone activities of hsp70 help to confer tolerance to heat, glucose deprivation, and drought. Overexpression of hsp70s in many organisms correlates with enhanced thermotolerance, altered growth, and development. To better understand the roles of hsp70 proteins in Arabidopsis, the molecular and physiological consequences of altered expression of the major heat shock cognate, Hsc70-1, were analyzed. Extensive efforts to achieve underexpression of Hsc70-1 mRNA using a full-length antisense cDNA resulted in no viable transgenic plants, suggesting that reduced expression is lethal. Constitutive overexpression of Hsc70-1 also appeared to be deleterious to viability, growth, and development because fewer transformants were recovered, and most were dwarfed with altered root systems. Despite being dwarfed, the overexpression plants progressed normally through four selected developmental stages. Heat treatment revealed that Hsc70-1 overexpression plants were more tolerant to heat shock (44 degrees C for 10 min). The elevated basal levels of HSC70-1 in transgenic plants led to delayed heat shock response of several heat shock genes. The data in this study suggest that tight regulation of Hsc70-1 expression is critical for the viability of Arabidopsis and that the functions of HSC70-1 contribute to optimum growth, development, thermotolerance, and regulation of the heat shock response.
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