ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Fatigue and paradoxical enhancement of heat response in C-fiber nociceptors from cross-modal excitation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Perception of first and second pain during offset analgesia.Experimental brain research · 2025Trial
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- Exploring the Use of the Current Perception Threshold in Pharyngeal Paresthesia Patients.Dysphagia · 2022Article
- Effects of repeated exposures to experimental cold pain stimulus on pain perception in healthy young Indian men.Medical journal, Armed Forces India · 2022Article
- The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach.Journal of translational medicine · 2020Article
- Thermal block of action potentials is primarily due to voltage-dependent potassium currents: a modeling study.Journal of neural engineering · 2019Article
- The Effect of Moxibustion Stimulation on Local and Distal Skin Temperature in Healthy Subjects.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Mechanically sensitive Aδ nociceptors that innervate bone marrow respond to changes in intra-osseous pressure.The Journal of physiology · 2017Article
- Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Normothermic Mouse Functional MRI of Acute Focal Thermostimulation for Probing Nociception.Scientific reports · 2016Article
- The influence of repeated pain stimulation on the emotional aspect of pain: a preliminary study in healthy volunteers.Journal of pain research · 2015Article
- The dynamics of pain: evidence for simultaneous site-specific habituation and site-nonspecific sensitization in thermal pain.The journal of pain · 2014Article
- Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses.Neuroscience · 2014Article
- Article
- NON-INVASIVE EVALUATION OF NERVE CONDUCTION IN SMALL DIAMETER FIBERS IN THE RAT.Physiology journal · 2013Article
- Article
- Article
- Short-term synaptic plasticity in the nociceptive thalamic-anterior cingulate pathway.Molecular pain · 2009Review
- Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.Journal of neurophysiology · 2009Article
- A role for polymodal C-fiber afferents in nonhistaminergic itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Fatigue refers to the decrement of response seen with repeated stimulation and is a prominent attribute of nociceptors. Whether fatigue in nociceptors involves transduction, spike initiation, or conduction mechanisms is unknown. We investigated systematically how electrical, mechanical, and heat conditioning stimuli (eCS, mCS, hCS) affected the subsequent response to a test-heat stimulus applied 5 sec later to the receptive field of cutaneous nociceptors. Standard teased-fiber techniques were used to record from mechano-heat-sensitive C-fiber afferents in the anesthetized monkey. The eCS was applied to the nerve trunk, whereas the hCS and mCS were applied to the heat-test site. For the eCS, the number of pulses rather than frequency of stimulation determined the level of fatigue. Fatigue varied inversely with the time interval between the eCS and the test stimulus. For comparable responses from the CS, the magnitude of fatigue was less after the mCS than after the eCS. The mCS (but not the eCS) sometimes evoked a paradoxical increase in response to the test-heat stimulus. Recovery from fatigue was significantly faster after the eCS and mCS than the hCS. The paradoxical enhancement after the mCS probably results from temporal summation of generator potentials produced by mechanical and heat stimulation and suggests that the time constant of the generator potential is on the order of seconds. Concurrent enhancement-fatigue effects may also explain why fatigue was less after the mCS than the eCS. The dependency of recovery from fatigue on the modality of the CS suggests that fatigue results from transduction-spike initiation mechanisms.
Indexed as
Identifiers
12805316PMC6740809W1584957869What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.