ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Cell-autonomous mechanisms and myelin-associated factors contribute to the development of Purkinje axon intracortical plexus in the rat cerebellum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
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- Consensus Paper: Cerebellar Development.Cerebellum (London, England) · 2016Review
- Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia.Acta neuropathologica communications · 2016Article
- Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage.Frontiers in cellular neuroscience · 2016Review
- Transient Developmental Purkinje Cell Axonal Torpedoes in Healthy and Ataxic Mouse Cerebellum.Frontiers in cellular neuroscience · 2016Article
- Article
- Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.Frontiers in cellular neuroscience · 2015Article
- Symposium in honor of Ferdinando Rossi: a passionate journey through the cerebellar mysteries.Cerebellum (London, England) · 2014Article
- Age-dependent decline of nogo-a protein in the mouse cerebrum.Cellular and molecular neurobiology · 2014Article
- Subcellular structural plasticity caused by the absence of the fast Ca(2+) buffer calbindin D-28k in recurrent collaterals of cerebellar Purkinje neurons.Frontiers in cellular neuroscience · 2014Article
- Beyond cell replacement: unresolved roles of NG2-expressing progenitors.Frontiers in neuroscience · 2014Article
- Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?Frontiers in neuroanatomy · 2012Article
- Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Nogo-A stabilizes the architecture of hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The highly specific connection patterns of the mature CNS are shaped through finely regulated processes of axon growth and retraction. To investigate the relative contribution of cell-autonomous mechanisms and extrinsic cues in these events, we examined the development of Purkinje axon intracortical plexus in the rat cerebellum. During the first postnatal week, several new processes sprout from focal swellings along the initial portion of the Purkinje neurite and spread in the granular layer. Intense structural plasticity occurs during the following week, with pruning of collateral branches and remodeling of terminal arbors. The mature distribution of the Purkinje infraganglionic plexus, confined within the most superficial portion of the granular layer, is attained at approximately postnatal day 15. A similar neuritic branching pattern is also developed by Purkinje cells grown in cultures of dissociated cerebellar cells or transplanted to extracerebellar CNS regions, suggesting that cell-autonomous mechanisms contribute to determining the Purkinje axon phenotype. The structural remodeling of Purkinje intracortical plexus is concomitant with the development of cerebellar myelin. To ask whether myelin-associated factors contribute to the morphological maturation of Purkinje neurites, we prevented normal myelinogenesis by killing oligodendrocyte precursors with 5'-azacytidine or by applying neutralizing antibodies against the myelin-associated neurite growth inhibitor Nogo-A. In both conditions, Purkinje axons retained exuberant branches, and the terminal plexus spanned the entire extent of the granular layer. Thus, the formation of Purkinje axon collaterals is, in part, controlled by intrinsic determinants, but their growth and distribution are regulated by environmental signals, among which are myelin-derived cues.
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Identifiers
12805301PMC6740793W1501424430What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.