ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm.Development (Cambridge, England) · 2024Article
- Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparison of the Response to the CXCR4 Antagonist AMD3100 during the Development of Retinal Organoids Derived from ES Cells and Zebrafish Retina.International journal of molecular sciences · 2022Article
- Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells' response to Pten deletion.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Potential Role of CXCL13/CXCR5 Signaling in Immune Checkpoint Inhibitor Treatment in Cancer.Cancers · 2022Review
- The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.Cell death & disease · 2020Article
- Pterygium Is Related to Short Axial Length.Cornea · 2020Article
- Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120.Cell death & disease · 2019Article
- HIV-associated neurodegeneration: exploitation of the neuronal cytoskeleton.Journal of neurovirology · 2019Review
- Convergence of signaling pathways underlying habenular formation and axonal outgrowth in zebrafish.Development (Cambridge, England) · 2017Article
- Knockdown of CXCL14 disrupts neurovascular patterning during ocular development.Developmental biology · 2017Article
- Temporal expression of CD184(CXCR4) and CD171(L1CAM) identifies distinct early developmental stages of human retinal ganglion cells in embryonic stem cell derived retina.Experimental eye research · 2017Article
- Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke.Journal of neuroinflammation · 2015Article
- sdf1 Expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish.Stem cells (Dayton, Ohio) · 2014Article
- Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND).AIDS research and therapy · 2014Review
- Expression of CXCL12 and CXCL14 during eye development in chick and mouse.Gene expression patterns : GEP · 2013Article
- CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear.Development (Cambridge, England) · 2012Article
- CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway.Stem cells (Dayton, Ohio) · 2012Article
- Emerging therapy for diabetic neuropathy: cell therapy targeting vessels and nerves.Endocrine, metabolic & immune disorders drug targets · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The chemokine receptor CXCR4 is expressed in the embryonic and mature CNS, yet its normal physiological function in neurons remains obscure. Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the survival of cultured embryonic retinal ganglion cell neurons even in the absence of other neurotrophic factors. This survival effect is mediated primarily through a cAMP-dependent pathway that acts through protein kinase A and MAP kinase. Addition of SDF-1 to a human neuronal cell line induces phosphorylation of p44/p42 MAP kinase and GSK3beta. Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion cells. The ligand of CXCR4, SDF-1, may therefore provide generalized trophic support to neurons during their development and maturation.
Indexed as
Identifiers
12805300PMC6740796W2166663391What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.