ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 91 citations in OpenAlex.
- Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.Alcoholism, clinical and experimental research · 2022Article
- Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster.Behavior genetics · 2017Article
- GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice.Psychopharmacology · 2015Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking.Alcoholism, clinical and experimental research · 2014Article
- Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.Current psychopharmacology · 2012Article
- Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice.Addiction biology · 2012Article
- Transcriptome profiling of embryonic development rate in rainbow trout advanced backcross introgression lines.Marine biotechnology (New York, N.Y.) · 2011Article
- Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice.Alcoholism, clinical and experimental research · 2011Article
- Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.Progress in molecular biology and translational science · 2011Review
- Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- Using expression genetics to study the neurobiology of ethanol and alcoholism.International review of neurobiology · 2010Review
- Article
- Genetic approaches to addiction: genes and alcohol.Addiction (Abingdon, England) · 2008Review
- Trait correlated expression combined with expression QTL analysis reveals biological pathways and candidate genes affecting water holding capacity of muscle.BMC genomics · 2008Article
- Genetic factors influencing alcohol dependence.British journal of pharmacology · 2008Review
- Mouse behavioral assays relevant to the symptoms of autism.Brain pathology (Zurich, Switzerland) · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute functional tolerance to ethanol develops during a single exposure to ethanol; it has been suggested to be a predisposing factor for the development of ethanol dependence. Genetic determinants of acute functional tolerance, as well as of ethanol dependence, have been clearly demonstrated. We describe a novel approach that uses a combination of selective breeding (to segregate genes contributing to the phenotype of interest, i.e., acute functional tolerance to the incoordinating effect of ethanol), quantitative trait locus analysis (to define chromosomal regions associated with acute functional tolerance), and DNA microarray technology (to identify differentially expressed genes in the brains of the selected lines of mice) to identify candidate genes for the complex phenotype of ethanol tolerance. The results indicate the importance of a signal transduction cascade that involves the glutamate receptor delta2 protein, the Ephrin B3 ligand, and the NMDA receptor, as well as a transcriptional regulatory protein that may be induced by activation of the NMDA receptor (zinc finger protein 179) and a protein that can modulate downstream responses to NMDA receptor activation (peroxiredoxin), in mediating acute tolerance to the incoordinating effect of ethanol.
Indexed as
Identifiers
12805289PMC6740804W2167685940What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.