ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Differential frequency dependence of P2Y1- and P2Y2- mediated Ca 2+ signaling in astrocytes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
- P2Y1 Receptor as a Catalyst of Brain Neurodegeneration.NeuroSci · 2022Review
- AβCellular and molecular life sciences : CMLS · 2022Article
- Receptor-specific CaiScience · 2021Article
- Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.International journal of molecular sciences · 2018Article
- Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization.Oncotarget · 2016Article
- The regulation of Sox2 and Sox9 stimulated by ATP in spinal cord astrocytes.Journal of molecular neuroscience : MN · 2015Article
- ATP as a multi-target danger signal in the brain.Frontiers in neuroscience · 2015Review
- Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.Neuropharmacology · 2015Article
- Neurovascular signaling in the brain and the pathological consequences of hypertension.American journal of physiology. Heart and circulatory physiology · 2014Review
- P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells.Purinergic signalling · 2012Review
- Pathophysiology of astroglial purinergic signalling.Purinergic signalling · 2012Review
- Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair.Stem cell reviews and reports · 2012Review
- Inhibition of the Ca²⁺-dependent K⁺ channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.British journal of pharmacology · 2011Article
- Immunogold electron microscopic evidence of in situ formation of homo- and heteromeric purinergic adenosine A1 and P2Y2 receptors in rat brain.BMC research notes · 2010Article
- The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia.British journal of pharmacology · 2010Article
- Role of nitric oxide on purinergic signalling in the cochlea.Purinergic signalling · 2010Article
- Desensitization of endothelial P2Y1 receptors by PKC-dependent mechanisms in pressurized rat small mesenteric arteries.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP is a key extracellular messenger that mediates the propagation of Ca 2+ waves in astrocyte networks in various regions of the CNS. ATP-mediated Ca 2+ signals play critical roles in astrocyte proliferation and differentiation and in modulating neuronal activity. The actions of ATP on astrocytes are via two distinct subtypes of P2Y purinoceptors, P2Y1 and P2Y2 receptors (P2Y1Rs and P2Y2Rs), G-protein coupled receptors that stimulate mobilization of intracellular Ca 2+ ([Ca 2+]i) via the phospholipase Cbeta-IP3 pathway. We report here that P2Y1R-mediated and P2Y2R-mediated Ca 2+ responses differentially show two forms of activity-dependent negative feedback. First, Ca 2+ responses mediated by either receptor exhibit slow depression that is independent of stimulation frequency. Second, responses mediated by P2Y1Rs, but not those mediated by P2Y2Rs, show rapid oscillations after high-frequency stimulation. We demonstrate that the oscillations are mediated by recruiting negative feedback by protein kinase C, and we map the site responsible for the effect of protein kinase C to Thr339 in the C terminus of P2Y1R. We propose that frequency-dependent changes in ATP-mediated Ca 2+ signaling pathways may modulate astrocyte function and astrocyte-neuron signaling in the CNS.
Indexed as
Identifiers
12805284PMC6740798W1858218191What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.