ArticleGenome research2003
Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 212 citations in OpenAlex.
- Structural Variations of Alu Elements in the Kuwaiti Population: Laying the Foundations for Forensic Medicine.Annals of human genetics · 2026Article
- Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain.bioRxiv : the preprint server for biology · 2026Article
- AnNAR genomics and bioinformatics · 2022Article
- Mobile element insertions and associated structural variants in longitudinal breast cancer samples.Scientific reports · 2021Article
- Alu retrotransposons and COVID-19 susceptibility and morbidity.Human genomics · 2021Review
- The Simons Genome Diversity Project: A Global Analysis of Mobile Element Diversity.Genome biology and evolution · 2020Article
- TypeTE: a tool to genotype mobile element insertions from whole genome resequencing data.Nucleic acids research · 2020Article
- A Two-State Model of Tree Evolution and Its Applications to Alu Retrotransposition.Systematic biology · 2018Article
- A computational reconstruction ofMobile DNA · 2018Article
- Analysis of lineage-specificMobile DNA · 2018Article
- Frequency of Alu insertions within the ACE and PR loci in Northwestern Mexicans.BMC research notes · 2017Article
- Genome-Wide Association Mapping Reveals Multiple QTLs Governing Tolerance Response for Seedling Stage Chilling Stress inFrontiers in plant science · 2017Article
- Population and clinical genetics of human transposable elements in the (post) genomic era.Mobile genetic elements · 2017Review
- Genetic differentiation and population structure of five ethnic groups of Punjab (North-West India).Molecular genetics and genomics : MGG · 2016Article
- Mitochondrial Genome and Nuclear Markers Provide New Insight into the Evolutionary History of Macaques.PloS one · 2016Article
- QTL Detection and Elite Alleles Mining for Stigma Traits in Oryza sativa by Association Mapping.Frontiers in plant science · 2016Article
- Polymorphic Alu Insertion/Deletion in Different Caste and Tribal Populations from South India.PloS one · 2016Article
- Article
- Evaluating intra- and inter-individual variation in the human placental transcriptome.Genome biology · 2015Article
- A genomic portrait of haplotype diversity and signatures of selection in indigenous southern African populations.PLoS genetics · 2015Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
We examine the distribution and structure of human genetic diversity for 710 individuals representing 31 populations from Africa, East Asia, Europe, and India using 100 Alu insertion polymorphisms from all 22 autosomes. Alu diversity is highest in Africans (0.349) and lowest in Europeans (0.297). Alu insertion frequency is lowest in Africans (0.463) and higher in Indians (0.544), E. Asians (0.557), and Europeans (0.559). Large genetic distances are observed among African populations and between African and non-African populations. The root of a neighbor-joining network is located closest to the African populations. These findings are consistent with an African origin of modern humans and with a bottleneck effect in the human populations that left Africa to colonize the rest of the world. Genetic distances among all pairs of populations show a significant product-moment correlation with geographic distances (r = 0.69, P < 0.00001). F(ST), the proportion of genetic diversity attributable to population subdivision is 0.141 for Africans/E. Asians/Europeans, 0.047 for E. Asians/Indians/Europeans, and 0.090 for all 31 populations. Resampling analyses show that approximately 50 Alu polymorphisms are sufficient to obtain accurate and reliable genetic distance estimates. These analyses also demonstrate that markers with higher F(ST) values have greater resolving power and produce more consistent genetic distance estimates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.