ArticleThe EMBO journal2003
Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
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Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine.Journal of visualized experiments : JoVE · 2017Pooled it
- Alternative Splicing in Plant Development and Abiotic Stress Responses: A Multifunctional Regulatory Mechanism.International journal of molecular sciences · 2026Review
- Alternative polyadenylation and metabolic profiling in young panicle development of hybrid rice and its parents.Rice (New York, N.Y.) · 2025Article
- Modular in vivo assembly of Arabidopsis FCA oligomers into condensates competent for RNA 3' processing.The EMBO journal · 2025Article
- C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1 promotes flowering with TAF15b by repressing the floral repressor gene FLOWERING LOCUS C.Molecules and cells · 2024Article
- Transcriptomic and metabolomic profiling reveals molecular regulatory network involved in flower development and phenotypic changes in two3 Biotech · 2024Article
- Cotranscriptional RNA processing and modification in plants.The Plant cell · 2023Review
- Toward a systems view on RNA-binding proteins and associated RNAs in plants: Guilt by association.The Plant cell · 2023Article
- Flowering time runs hot and cold.Plant physiology · 2022Review
- Moderate Soil Drying-Induced Alternative Splicing Provides a Potential Novel Approach for the Regulation of Grain Filling in Rice Inferior Spikelets.International journal of molecular sciences · 2022Article
- A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis.Genome biology · 2022Article
- The flowering transition pathways converge into a complex gene regulatory network that underlies the phase changes of the shoot apical meristem inFrontiers in plant science · 2022Article
- Calcium-dependent protein kinase CPK32 mediates calcium signaling in regulating Arabidopsis flowering time.National science review · 2022Article
- Divergence of flowering-related genes to control flowering in five Euphorbiaceae genomes.Frontiers in plant science · 2022Article
- How alternative splicing changes the properties of plant proteins.Quantitative plant biology · 2022Review
- Recent advances in the chromatin-based mechanism ofFrontiers in plant science · 2022Review
- Alternative Splicing ofInternational journal of molecular sciences · 2021Article
- Beyond the Genetic Pathways, Flowering Regulation Complexity inInternational journal of molecular sciences · 2021Review
- Antagonistic activities of cotranscriptional regulators within an early developmental window setProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
54 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The timing of the transition to flowering is critical for reproductive success in plants. Arabidopsis FCA encodes an RNA-binding protein that promotes flowering. FCA expression is regulated through alternative processing of its pre-mRNA. We demonstrate here that FCA negatively regulates its own expression by ultimately promoting cleavage and polyadenylation within intron 3. This causes the production of a truncated, inactive transcript at the expense of the full-length FCA mRNA, thus limiting the expression of active FCA protein. We show that this negative autoregulation is under developmental control and requires the FCA WW protein interaction domain. Removal of introns from FCA bypasses the autoregulation, and the resulting increased levels of FCA protein overcomes the repression of flowering normally conferred through the up-regulation of FLC by active FRI alleles. The negative autoregulation of FCA may therefore have evolved to limit FCA activity and hence control flowering time.
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