ArticleThe EMBO journal2003
A novel boundary element may facilitate independent gene regulation in the Antennapedia complex of Drosophila.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 103 citations in OpenAlex.
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- Topological screen identifies hundreds of Cp190- and CTCF-dependentScience advances · 2023Article
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Article
- Essential role of Cp190 in physical and regulatory boundary formation.Science advances · 2022Article
- GAGA factor: a multifunctional pioneering chromatin protein.Cellular and molecular life sciences : CMLS · 2021Review
- Mutational analysis identifies functional Rap1, Su(Hw), and CTCF insulator sites in Arabidopsis thaliana.Plant cell reports · 2020Article
- BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila.Nature communications · 2019Article
- Selective interactions between diverse STEs organize the ANT-C Hox cluster.Scientific reports · 2018Article
- Visualization of Transvection in Living Drosophila Embryos.Molecular cell · 2018Article
- Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation.Cellular and molecular life sciences : CMLS · 2018Review
- High-resolution TADs reveal DNA sequences underlying genome organization in flies.Nature communications · 2018Article
- Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.Molecular and cellular biology · 2017Article
- Sex combs reduced (Scr) regulatory region of Drosophila revisited.Molecular genetics and genomics : MGG · 2017Article
- The GAGA factor regulatory network: Identification of GAGA factor associated proteins.PloS one · 2017Article
- Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters.World journal of biological chemistry · 2016Review
- An Organizational Hub of Developmentally Regulated Chromatin Loops in the Drosophila Antennapedia Complex.Molecular and cellular biology · 2015Article
- A variably occupied CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex.Molecular and cellular biology · 2015Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The intrinsic enhancer-promoter specificity and chromatin boundary/insulator function are two general mechanisms that govern enhancer trafficking in complex genetic loci. They have been shown to contribute to gene regulation in the homeotic gene complexes from fly to mouse. The regulatory region of the Scr gene in the Drosophila Antennapedia complex is interrupted by the neighboring ftz transcription unit, yet both genes are specifically activated by their respective enhancers from such juxtaposed positions. We identified a novel insulator, SF1, in the Scr-ftz intergenic region that restricts promoter selection by the ftz-distal enhancer in transgenic embryos. The enhancer-blocking activity of the full-length SF1, observed in both embryo and adult, is orientation- and enhancer-independent. The core region of the insulator, which contains a cluster of GAGA sites essential for its activity, is highly conserved among other Drosophila species. SF1 may be a member of a conserved family of chromatin boundaries/insulators in the HOM/Hox complexes and may facilitate the independent regulation of the neighboring Scr and ftz genes, by insulating the evolutionarily mobile ftz transcription unit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.