ArticleThe EMBO journal2003
The thyroid hormone receptor antagonizes CREB-mediated transcription.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 72 citations in OpenAlex.
- Thyroid Hormone Action by Genomic and Nongenomic Molecular Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Thyroid Hormone Upregulates Cav1.2 Channels in Cardiac Cells via the Downregulation of the Channels' β4 Subunit.International journal of molecular sciences · 2024Article
- High concentration of estradiol has a negative correlation with free thyroxine during the second trimester of pregnancy.Endocrine connections · 2022Article
- Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease.Biomedicines · 2022Review
- Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors.Scientific reports · 2022Article
- Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores.Scientific reports · 2021Article
- Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.JCI insight · 2021Article
- Targeting transcriptional regulators for treatment of anaplastic thyroid cancer.Journal of cancer metastasis and treatment · 2021Article
- Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague⁻Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways.International journal of molecular sciences · 2018Article
- Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis.Journal of cell science · 2017Article
- Impaired Repressor Function in SUMOylation-Defective Thyroid Hormone Receptor Isoforms.European thyroid journal · 2016Article
- Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation.Molecular medicine (Cambridge, Mass.) · 2016Article
- Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph.PloS one · 2015Article
- The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.Endocrinology · 2014Article
- Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Article
- Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor.Endocrinology · 2012Article
- Early thyroid hormone-induced gene expression changes in N2a-β neuroblastoma cells.Journal of molecular neuroscience : MN · 2011Article
- The thyroid hormone receptors as modulators of skin proliferation and inflammation.The Journal of biological chemistry · 2011Article
- Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes.Molecular endocrinology (Baltimore, Md.) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combinatorial regulation of transcription involves binding of transcription factors to DNA as well as protein-protein interactions between them. In this paper, we demonstrate the existence of a mutual transcriptional antagonism between the thyroid hormone receptor (TR) and the cyclic AMP response element binding protein (CREB), which involves a direct association of both transcription factors. TR inhibits transcriptional activity of CREB and represses activation of cAMP response element (CRE)-containing promoters. TR does not bind to the CRE in vitro, but in vivo the liganded receptor is tethered to the promoter through protein-protein interactions. In turn, expression of CREB reduces TR-dependent transcriptional responses. The association of TR with CREB inhibits the ability of protein kinase A to phosphorylate CREB at Ser133, and leads to a reduction in the ligand-dependent recruitment of the p160 coactivators by TR. These results indicate the existence of a transcriptional cross-talk between CREB and TR signalling pathways, which can have important functional consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.